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Measurements of cardiac troponin I and creatine kinase myocardium isoform in dogs with diabetic ketoacidosis

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Abstract

Diabetic ketoacidosis (DKA) is a complication of diabetes mellitus (DM) which may cause cardiac injury. The study aimed to compare concentrations of cardiac troponin I (cTnI) and creatine kinase myocardium isoform (CK-MB) in DKA and normal dogs and determine the relationship between cTnI and CK-MB concentrations and blood profile values, complications, and the risk of death. Plasma samples from 20 normal and 24 DKA dogs were collected. The cTnI concentration of DKA dogs (0.053 [0.034–0.200] ng/ml) was higher than those of normal dogs (0.020 [0.015–0.043] ng/ml) (p < 0.0001). Dogs with higher cTnI concentration had a higher risk of death than those with lower cTnI concentrations (HR 12.34; 95 % CI 1.66, 91.97). DKA dogs (203.5 [142.8–290.0] U/l) had higher CK-MB concentrations than normal dogs (90 [78–134.5] ng/ml) (p = 0.008). In conclusion, cTnI and CK-MB concentrations increase in DKA dogs. With higher cTnI concentrations, dogs have a higher risk of death.

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Authors and Affiliations

  1. Department of Veterinary Medicine, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, 10330, Thailand

    Sirilak Disatian Surachetpong, Pleansaung Vichit & Vachira Hunprasit

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  1. Sirilak Disatian Surachetpong
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  2. Pleansaung Vichit
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  3. Vachira Hunprasit
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Correspondence to Sirilak Disatian Surachetpong.

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Funding

The study was supported by the Faculty of Veterinary Science Chulalongkorn University Research Fund year 2015 (Grant number RG6/2558).

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study protocol was approved by the Animal Care and Use Committee, Faculty of Veterinary Science, Chulalongkorn University, Thailand (Animal Use Protocol No. 1431087).

This article does not contain any studies with human participants performed by any of the authors.

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Surachetpong, S.D., Vichit, P. & Hunprasit, V. Measurements of cardiac troponin I and creatine kinase myocardium isoform in dogs with diabetic ketoacidosis. Comp Clin Pathol 25, 1185–1191 (2016). https://doi.org/10.1007/s00580-016-2326-x

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  • DOI: https://doi.org/10.1007/s00580-016-2326-x

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