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Evidence for linkage of a new region (11p14) to eczema and allergic diseases

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Abstract

Asthma, allergic rhinitis (AR) and atopic dermatitis also called eczema are allergic co-morbidites, which are likely to depend on pleiotropic genetic effects as well as on specific genetic factors. After a previous genome-wide linkage screen conducted for asthma and AR in a sample of 295 French EGEA families ascertained through asthmatic subjects, the aim here was to search for genetic factors involved in eczema and more particularly the ones shared by the three allergic diseases using the same EGEA data. In this sake, eczema and phenotypes of “allergic disease” accounting for the joint information on the presence/absence of the three diseases were examined by linkage analyses using the maximum likelihood binomial method. A fine mapping was carried out in regions detected for potential linkage, followed by association studies using the family-based association test (FBAT). Evidence for linkage to 11p14 region was shown for “allergic disease” and eczema. Linkage was also indicated between eczema and 5q13 and between “allergic disease” and both 5p15 and 17q21 regions. Fine mapping supported the evidence of linkage to 11p14 and FBAT analyses showed the association between “allergic disease” and a marker located at the linkage peak on 11p14. Further investigations in this region will allow identifying genetic factor(s) which could have pleiotropic effect in the three allergic diseases.

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Acknowledgments

This work was partly supported by EU Framework Programme for Research, contract no. FOOD-CT-2004-506378, the GA2LEN project, Global Allergy and Asthma European Network.

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Authors and Affiliations

  1. INSERM U535, Hôpital Paul Brousse, Bâtiment Leriche, B.P. 1000, 94817, Villejuif Cedex, France

    Michel Guilloud-Bataille & Marie-Hélène Dizier

  2. Univ Paris-Sud, IFR69, Villejuif, France

    Michel Guilloud-Bataille & Marie-Hélène Dizier

  3. INSERM, U794, Evry, France

    Emmanuelle Bouzigon & Florence Demenais

  4. Univ d’Evry, Evry, France

    Emmanuelle Bouzigon & Florence Demenais

  5. INSERM, U707, Paris, France

    Isabella Annesi-Maesano

  6. Univ Pierre et Marie Curie-Paris 6, Paris, France

    Isabella Annesi-Maesano

  7. Clinique des Maladies Respiratoires, INSERM U454, Hôpital Arnaud de Villeneuve, Montpellier, France

    Jean Bousquet

  8. Service de Pneumologie-Allergologie, Hôpital Nord, Marseille, France

    Denis Charpin

  9. Service de Pneumologie, Centre Hospitalier Lyon-Sud, Pierre Benite, France

    Frédéric Gormand

  10. INSERM U436, Paris, France

    Joëlle Hochez

  11. Centre de Diagnostic et Traitement de l’Asthme, Hôpital Trousseau, Paris, France

    Jocelyne Just

  12. Centre National de Génotypage, Evry, France

    Arnaud Lemainque & Mark Lathrop

  13. INSERM, U780, Villejuif, France

    Nicole Le Moual, Marie-Pierre Oryszczyn & Francine Kauffmann

  14. Laboratoire d’Exploration Fonctionnelle, Hôpital Calmette, Lille, France

    Régis Matran

  15. INSERM U408, Paris, France

    Françoise Neukirch

  16. Service de Pneumologie Infantile, Hôpital Necker, Paris, France

    Evelyne Paty

  17. Département de Médecine Aigüe Spécialisée, CHU Michallon, Grenoble, France

    Isabelle Pin

  18. Service de Pneumo-allergologie, Hôpital Ste Marguerite, Marseille, France

    Daniel Vervloet

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  1. Michel Guilloud-Bataille
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  2. Emmanuelle Bouzigon
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  3. Isabella Annesi-Maesano
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  19. Florence Demenais
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  20. Marie-Hélène Dizier
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Correspondence to Marie-Hélène Dizier.

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Guilloud-Bataille, M., Bouzigon, E., Annesi-Maesano, I. et al. Evidence for linkage of a new region (11p14) to eczema and allergic diseases. Hum Genet 122, 605–614 (2008). https://doi.org/10.1007/s00439-007-0439-7

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  • DOI: https://doi.org/10.1007/s00439-007-0439-7

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