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Increased expression of Trop2 correlates with poor survival in extranodal NK/T cell lymphoma, nasal type

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Abstract

Human trophoblastic cell surface antigen 2 (Trop2) has been suggested to play an important role in the development of solid tumors. However, the expression of Trop2 in extranodal NK/T cell lymphoma, nasal type (ENKTL) and the relationship with the clinical characteristics of this disease remain poorly understood. In this study, one-step quantitative PCR reverse transcription-polymerase chain reaction and immunohistochemical staining with tissue sections were employed to evaluate the expression of Trop2 in ENKTL. Furthermore, the relationship between Trop2 expression and prognosis of ENKTL was investigated. Expression of Trop2 mRNA and protein was significantly higher in ENKTL tissue than in corresponding non-lymphomatous tissue (p = 0.04 and p < 0.001, respectively). Expression of Trop2 protein in ENKTL was associated with lymph node involvement and poor overall survival (p = 0.045 and p = 0.018, respectively). Kaplan–Meier analysis and the logrank test indicated that lymph node involvement (p = 0.0481), single therapy strategy (p = 0.0037), and high expression of Trop2 (p = 0.0042) are significantly correlated with poor prognosis of ENKTL patients. The data suggest that Trop2 expression reflects a more malignant phenotype and may serve as an unfavorable prognostic factor for ENKTL.

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Acknowledgments

This work is supported in part by grants from the Director Foundation of the National Natural Science Foundation (No. 81241074), China and the Social Development and Applied Research Projects of Nantong (No.K2010054, No.K2010048), Nantong, China.

Conflict of interest

The authors have no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Nanjing Medical University, No.121 Jiang jia yuan, Nanjing, 210011, China

    Renjie Chen & Dawei Zhang

  2. Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing, 210011, China

    Meiping Lu

  3. Department of Hematology and Oncology, Jiangsu Provincial Hospital, No.65 Jiangsu Road, Nanjing, 210029, China

    Jun Wang & Jiaren Xu

  4. Jiangsu Provincial Blood Center, No.179 Longpan Road, Nanjing, 210042, China

    Hong Lin

  5. Department of Pathology, Affiliated Hospital of Nantong University, No.20 Xisi Road, Nantong, 226001, China

    Huijun Zhu

  6. Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing, 210011, China

    Weiming Zhang

  7. Department of Pathology, The Second Affiliated Hospital of Nanjing Medical University, No.121 Jiang jia yuan, Nanjing, 210011, China

    Lin Xiong

  8. Department of Otolaryngology-Head and Neck Surgery, Yiji Shan Hospital of Wannan Medical College, No.92 Zheshan Xi Road, Wuhu, 241000, China

    Jun Ma

  9. Department of Otolaryngology-Head and Neck Surgery, Jiangsu Provincial Hospital, No.65 Jiangsu Road, Nanjing, 210029, China

    Yuan Mao

  10. Huadong Medical Institute of Biotechnology, No.293 Zhongshan Dong Road, Nanjing, 210002, China

    Jin Zhu

  11. The Key Laboratory of Cancer Biomarkers, Prevention & Treatment Cancer Center and The Key Laboratory of Antibody Technique of Ministry of Health, Nanjing Medical University, No.140 Hanzhong Road, Nanjing, 210029, China

    Jin Zhu

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  1. Renjie Chen
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  2. Meiping Lu
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  3. Jun Wang
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  4. Dawei Zhang
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  5. Hong Lin
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  6. Huijun Zhu
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  7. Weiming Zhang
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  8. Lin Xiong
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  9. Jun Ma
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  10. Yuan Mao
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  11. Jin Zhu
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  12. Jiaren Xu
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Corresponding author

Correspondence to Jiaren Xu.

Additional information

Renjie Chen and Meiping Lu contributed equally to this work.

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Chen, R., Lu, M., Wang, J. et al. Increased expression of Trop2 correlates with poor survival in extranodal NK/T cell lymphoma, nasal type. Virchows Arch 463, 713–719 (2013). https://doi.org/10.1007/s00428-013-1475-4

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  • DOI: https://doi.org/10.1007/s00428-013-1475-4

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