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Microbial spectrum and antibiotic sensitivity in infantile dacryocystitis

  • Inflammatory Disorders
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Abstract

Purpose

To identify the characteristics and the spectrum of microbial agents of infantile dacryocystitis and to assess the trends in both antibiotic sensitivities and pathogens over the past 10 years.

Methods

The microbial and medical records of 546 culture-proven patients (546 eyes) of infantile dacryocystitis diagnosed at Henan Eye Hospital between January 2009 and December 2018 were retrospectively reviewed. Patient demographics, microbial analysis, and susceptibility rates to various antibiotics were done. A chi-squared test for trends was applied to evaluate changes in antibiotic susceptibility and microbial spectrum over time.

Results

A total of 546 patients with infantile dacryocystitis were documented. The average age was 2.97 ± 4.15 months, and 42.7% were female. The proportion of gram-positive microbes, gram-negative microbes, and fungi was 80.2, 19.4, and 0.4%, respectively. Minocycline was sensitive to gram-positive bacteria (98.0%). Imipenem was sensitive to gram-negative bacteria (89.2%). Increasing susceptibility was observed in two bacterial isolates: Staphylococcus aureus (P = 0.005) and Streptococcus mitis (P = 0.001). Decreasing susceptibility was observed in one bacterial isolate: Staphylococcus epidermidis (P < 0.0001). Increasing microbial susceptibility over time was detected for 12 antibiotics. Decreasing microbial sensitivity was observed for one antibiotic.

Conclusions

The most common cause of infantile dacryocystitis is Staphylococcus epidermidis. Though a significant trend towards increasing microbial sensitivity to some antibiotics was observed, including glycopeptides, cephalosporins, fluoroquinolones, tetracyclines, and lincosamides, a significant trend towards decreasing microbial sensitivity to amikacin was also detected.

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Acknowledgments

The authors thank Adjunct Faculty Tarek El-Sawy from Stanford University for his critically reviewed the study proposal. The authors are also grateful for the support from Henan Key Laboratory of Ophthalmology and Visual Science and the National Key Clinical Specialties Construction Program of China.

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Author notes

  1. Huiling Qing and Zhengwei Yang contributed equally to this work.

Authors and Affiliations

  1. Department of Ophthalmology, Henan Eye Hospital, Henan Eye Institute, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, NO.7, Wei-wu Road, Zhengzhou, 450003, China

    Huiling Qing, Zhengwei Yang, Menghai Shi, Junge Zhang, Shengtao Sun & Lei Han

Authors
  1. Huiling Qing
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  2. Zhengwei Yang
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  3. Menghai Shi
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  4. Junge Zhang
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Huiling Qing, Zhengwei Yang, Menghai Shi, Junge Zhang, Shengtao Sun, and Lei Han. The first draft of the manuscript was written by Zhengwei Yang, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Huiling Qing.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in this study were conducted according to the ethical principles of the Declaration of Helsinki, and the study protocol was reviewed by the Ethics Committee of Henan Eye Institute Review Board.

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Informed consent was obtained from all individual participants included in the study.

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Qing, H., Yang, Z., Shi, M. et al. Microbial spectrum and antibiotic sensitivity in infantile dacryocystitis. Graefes Arch Clin Exp Ophthalmol 259, 1263–1272 (2021). https://doi.org/10.1007/s00417-020-05026-7

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  • DOI: https://doi.org/10.1007/s00417-020-05026-7

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