Abstract
Purpose
To investigate the effect of topical prostaglandin (PG) eyedrops on the biomechanics and shape of the cornea.
Methods
Consecutive patients with primary open-angle glaucoma who had been treated with the same anti-glaucoma PG (114 eyes, 57 patients) or β-blocker (36 eyes, 18 patients) eyedrops in 1 eye alone for more than 3 months at Inouye Eye Hospital or Miyata Eye Hospital. The biomechanical properties of the cornea were measured using a Corvis ST device (Oculus, Wetzlar, Germany). Corneal tomography was measured with a Casia 1 or 2 (Tomey Corp., Nagoya, Japan). The biomechanical parameters and tomographic features of the cornea were compared between PG-treated eyes, β-blocker-treated eyes, and contralateral eyes using a mixed-effect model adjusted for intraocular pressure and corneal thickness and a linear model adjusted for age, sex, intraocular pressure, and corneal thickness.
Results
The PG-treated eyes had a significantly smaller applanation 1 time, the highest concavity radius, and a larger deformation amplitude than the contralateral eyes. Also, the PG-treated eyes had a significantly smaller applanation 1 time and applanation 2 velocity but a larger peak distance than the β-blocker-treated eyes. There were no significant differences in any of the Casia parameters between the PG-treated eyes and the contralateral eyes.
Conclusion
The results of this study suggest that topical PG makes biochemical changes to the cornea but does not alter its shape.
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Abbreviations
- A1:
-
First applanation
- A2:
-
Second applanation
- HC:
-
Highest concavity
- logMAR:
-
Logarithm of the minimum angle of resolution
- MMP:
-
Matrix metalloproteinase
- PG:
-
Prostaglandin
- POAG:
-
Primary open-angle glaucoma
- SITA:
-
Swedish Interactive Threshold Algorithm
- TIMP:
-
Tissue inhibitors of metalloproteinase
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Acknowledgments
The authors would like to acknowledge Dr. Toshihito Furukawa (Biostatistical Research Co., Ltd., Tokyo) for the statistical analyses and Editage (www.editage.jp) for English language editing services.
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Dr. Amano has received research grants from Santen Pharmaceutical and speaker honoraria from Santen Pharmaceutical, Senju Pharmaceutical, Alcon, AMO, HOYA, and Otsuka Pharmaceutical. Dr. Nejima has received speaker honoraria from Santen Pharmaceutical, Senju Pharmaceutical, Alcon, and Nitoh Medic. Dr. Inoue has received research grants from Santen Pharmaceutical, Alcon, Senju Pharmaceutical, Allergan Japan, Teijin Pharma Limited, IQVIA Services Japan, Mayo Corporation, and Eli Lilly Japan and speaker honoraria from Santen Pharmaceutical, Otsuka Pharmaceutical, Senju Pharmaceutical, Kowa Pharmaceutical, Allergan Japan, Novartis Pharma, and Wakamoto Pharmaceutical. Dr. Miyata has received research grants from Santen Pharmaceutical, Senju Pharmaceutical, Alcon, Wakamoto Pharmaceutical, HOYA, Shionogi Pharmaceutical, Novartis Pharma, Sucampo Pharma LLC, Bayer, Chugai Pharmaceutical, and Kissei Pharmaceutical and speaker honoraria from Santen Pharmaceutical, Senju Pharmaceutical, Alcon, AMO, Otsuka Pharmaceutical, Wakamoto Pharmaceutical, HOYA, Kowasoyaku, Chuosangyo, Tomey, Staar Japan, Alcon Pharma, and Japan Tissue Engineering.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of Inouye Eye Hospital and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Informed consent was obtained from all individual participants included in the study.
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Amano, S., Nejima, R., Inoue, K. et al. Effect of topical prostaglandins on the biomechanics and shape of the cornea. Graefes Arch Clin Exp Ophthalmol 257, 2213–2219 (2019). https://doi.org/10.1007/s00417-019-04435-7
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DOI: https://doi.org/10.1007/s00417-019-04435-7