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Effect of prostaglandin analogues on the biomechanical corneal properties in patients with open-angle glaucoma and ocular hypertension measured with dynamic scheimpflug analyzer

  • Glaucoma
  • Published:
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Abstract

Purpose

The aim of the study is to evaluate the effect of topical prostaglandin (PG) treatment on the corneal biomechanical properties in treatment-naïve patients with either primary open-angle glaucoma (POAG) or ocular hypertension (OHT) using the Corvis ST device.

Methods

This is an observational study. We analyzed the Corvis ST dynamic corneal response parameters of our database using the newest software available. Thirty-four eyes of 34 patients were included. They were all newly diagnosed and treatment-naïve. Patients were evaluated at baseline and after 6 months of treatment with prostaglandin analogues.

Ultrasound pachymetry, Optical Coherence Tomography (OCT) and a 24–2 visual field test were performed in baseline visit. Goldman Applanation Tonometry (GAT-IOP) and Corvis ST dynamic corneal response parameters were registered at baseline and at the 6-month visit.

Results

After 6 months of treatment, the IOP decrease (Δ) values obtained with the different tonometers were ΔGAT -6.5 ± 3.7, ΔIOPnct -4.4 ± 5.7 and ΔbIOP -3.8 ± 5.4. The differences between ΔGAT vs ΔIOPnct, ΔGAT vs ΔbIOP, and ΔIOPnct vs ΔbIOP, were statistically significant (p < 0.05 for all comparisons). Statistically significant lower values of the stress–strain index (SSI) (1.77 ± 0.3 at baseline vs 1.54 ± 0.27 at the 6-month visit) were found (p = 0.0002).

Conclusion

The SSI provided by the Corvis ST seems to decrease significantly after topical prostaglandin therapy. We believe that our results support the hypothesis that topical PG therapy does decrease the corneal stiffness and thus, that the ocular hypotensive effect of these drugs is overestimated if GAT is used for IOP measurement.

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Acknowledgements

Thanks to the doctors Castejon M.A., Gutiérrez-Ortiz, C., Paz-Moreno Arrones J., belonging to the Glaucoma Unit at Hospital Príncipe de Asturias, who have participated together with the authors, in the recruitment and follow-up of the patients who were included in the study.

Funding

The Foundation for Biomedical Research of the ‘‘Hospital Universitario Príncipe de Asturias’’ has awarded our group a grant codified as FIB-PI21/-04.

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Authors and Affiliations

  1. Universitary Hospital “Infanta Leonor”, Avenida de la Gran Vía del Este 80, Madrid, 28031, Spain

    Marta Isabel Martínez-Sánchez

  2. Universitary Hospital “Príncipe de Asturias”, Alcalá Meco S/N, Alcalá de Henares, Madrid, 28805, Spain

    Gema Bolívar, Haris Sideroudi & Miguel A. Teus

  3. Universidad de Alcalá, Plaza de San Diego S/N, Alcalá de Henares, Madrid, 28801, Spain

    Gema Bolívar & Miguel A. Teus

Authors
  1. Marta Isabel Martínez-Sánchez
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  2. Gema Bolívar
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  3. Haris Sideroudi
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  4. Miguel A. Teus
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Corresponding author

Correspondence to Marta Isabel Martínez-Sánchez.

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Ethics approval and consent to participate

The research involves human participants and all procedures performed in studies involving human participants were in accordance with the ethical standards of the local Institutional Review Board (CEIm) of the Hospital Universitario Príncipe de Asturias with the number OE 15/2020 and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study after being informed about all the potential risks and benefits of the study.

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The authors declare no competing interests.

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Martínez-Sánchez, M.I., Bolívar, G., Sideroudi, H. et al. Effect of prostaglandin analogues on the biomechanical corneal properties in patients with open-angle glaucoma and ocular hypertension measured with dynamic scheimpflug analyzer. Graefes Arch Clin Exp Ophthalmol 260, 3927–3933 (2022). https://doi.org/10.1007/s00417-022-05752-0

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