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Suicidal ideation in early-onset Parkinson’s disease

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Abstract

Objective

Patients with early-onset Parkinson’s disease (EOPD) often suffer from more frequent depression than those with late-onset Parkinson’s disease (LOPD). However, the clinical characteristics of suicidal ideation (SI) in EOPD remains unknown. This study aimed to explore the prevalence, related factors, and predictive factors of SI in EOPD patients as well as comparison of the prevalence in LOPD patients.

Methods

We conducted a case–control, cross-sectional, and longitudinal study. Propensity score matching (PSM) was used to balance the characteristics between EOPD (N = 577) and LOPD patients (N = 2973). The diagnosis of SI was based on the assessment of the Beck Depression Inventory (BDI). EOPD patients with a disease duration < 5 years (N = 96) were prospectively followed-up for exploring the predictors for the development of SI. Two forward binary logistic regression models were respectively used to explore the associated and predictive factors of SI.

Results

After PSM, EOPD patients showed significantly higher prevalence of SI than LOPD patients (22.0 vs. 13.3%, P < 0.001). Twenty EOPD patients (20.8%) developed SI and none of them reported suicidal behaviors after a median of 2.7 (IQR = 1.6–4.1) years. Depression, dyskinesia, non-smoking, lower education, and higher Non-Motor Symptoms Scale (NMSS) score were independently associated with the presence of SI. Depression at baseline was the only independent risk factor for the future occurrence of SI.

Conclusions

Our study highlights the necessity to screen SI in patients with EOPD especially for those with depression.

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Acknowledgements

The authors thank the patients and their families for their participation in the study.

Funding

This study was supported by the National Key Research and Development Program of China (Grant no. 2016YFC0901504), the 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (Grant no. ZYJC18038), and the National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University (Grant no. Z2018B08). ORW has received a grant from the National Natural Science Fund of China (Grant no. 81901293).

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Authors and Affiliations

  1. Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China

    Ruwei Ou, Qianqian Wei, Yanbing Hou, Lingyu Zhang, Kuncheng Liu, Xiangwei Kong, Shuying Li, Lan Wang, Xianran Xu, Xiaojing Gu, Junyu Lin, Zheng Jiang, Jiao Liu, Wei Song, Bei Cao & Huifang Shang

Authors
  1. Ruwei Ou
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  2. Qianqian Wei
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  3. Yanbing Hou
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  4. Lingyu Zhang
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  14. Wei Song
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  15. Bei Cao
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  16. Huifang Shang
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Contributions

RO: Conception, organization, and execution; data collection and statistical analysis; drafting the manuscript. HS: Conception and organization; manuscript review and critique; responsible for the overall content as the guarantor. QW, YH, LZ, KL, XK, SL, LW, XX, JuL, ZJ, JiL, WS, BC: Execution; data collection; patients’ follow up; manuscript review and critique. XG: Execution; data collection, English editing.

Corresponding author

Correspondence to Huifang Shang.

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Conflicts of interest

Ruwei Ou, Qianqian Wei, Yanbing Hou, Lingyu Zhang, Kuncheng Liu, Xiangwei Kong, Shuying Li, Lan Wang, Xianran Xu, Xiaojing Gu, Junyu Lin, Zheng Jiang, Jiao Liu, Wei Song, Bei Cao, and Huifang Shang report no disclosures relevant to the manuscript.

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Ou, R., Wei, Q., Hou, Y. et al. Suicidal ideation in early-onset Parkinson’s disease. J Neurol 268, 1876–1884 (2021). https://doi.org/10.1007/s00415-020-10333-4

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  • DOI: https://doi.org/10.1007/s00415-020-10333-4

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