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Oral lesion as the primary diagnosis of non-Hodgkin’s lymphoma: a 20-year experience from an oral pathology service and review of the literature

  • Head and Neck
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Abstract

Purpose

We aimed to investigate the frequency and clinicopathological features of oral NHL in our institution as well as to compare the data gathered from other oral pathology and general pathology services published in the literature.

Methods

Clinical records of patients diagnosed with NHL exclusively affecting the oral cavity were reviewed from 1997 to 2017. Additionally, a review of the literature over a 20-year period was conducted aiming to examine articles on oral NHLs.

Results

Oral NHLs represented 0.1% (n = 98) of the total number of biopsies (68,229) received during the period evaluated (1997–2017). The mean age at the diagnosis was 47 years. Most patients were white (67.3%). A nodular lesion was the most frequent presentation (54.9%) and pain was described in 47.1% of the cases. The most common diagnosis was diffuse large B cell lymphoma (42%) followed by plasmablastic lymphoma (24%). Only 19 articles were included in the review of the literature.

Conclusions

Although NHLs are rare in the oral cavity, clinicians and surgeons have an important role in promptly diagnosing lymphomatous lesions to refer the patient to a proper treatment.

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Authors and Affiliations

  1. Oral and Maxillofacial Pathology Department, School of Dentistry, University of São Paulo, Av. Professor Lineu Prestes, 2227, Cidade Universitária, São Paulo, SP, 05508-000, Brazil

    Natália Kusuke, Marcos Custódio & Suzana C. O. M. de Sousa

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  1. Natália Kusuke
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  2. Marcos Custódio
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  3. Suzana C. O. M. de Sousa
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Correspondence to Marcos Custódio.

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The authors state that they have no conflicts of interest.

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All the procedures performed in this study involving the patient were in accordance with the ethical standards of the Institutional and/or National Research Committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The approval of the local ethics committee is present in the methods section in this article.

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Kusuke, N., Custódio, M. & de Sousa, S.C.O.M. Oral lesion as the primary diagnosis of non-Hodgkin’s lymphoma: a 20-year experience from an oral pathology service and review of the literature. Eur Arch Otorhinolaryngol 276, 2873–2879 (2019). https://doi.org/10.1007/s00405-019-05544-z

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