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Normal meninges harbor oncogenic somatic mutations in meningioma-driver genes

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Acknowledgements

The authors would like to thank the following associations: ARSLA, CSC, France DFT, Fondation ARSEP, Fondation Vaincre Alzheimer, France Parkinson. The Neuro-CEB Neuropathology network includes: Dr. Franck Letournel (CHU Angers), Dr. Marie-Laure Martin-Négrier (CHU Bordeaux), Dr. Maxime Faisant (CHU Caen), Pr. Catherine Godfraind (CHU Clermont-Ferrand), Pr. Claude-Alain Maurage (CHU Lille), Dr. Vincent Deramecourt (CHU Lille), Dr. Mathilde Duchesne (CHU Limoges), Dr. David Meyronnet (CHU Lyon), Dr. Clémence Delteil (CHU Marseille), Pr. Valérie Rigau (CHU Montpellier), Dr. Fanny Vandenbos-Burel (Nice), Pr. Danielle Seilhean (CHU PS, Paris), Dr. Susana Boluda (CHU PS, Paris), Dr. Isabelle Plu (CHU PS, Paris), Dr. Dan Christian Chiforeanu (CHU Rennes), Dr. Florent Marguet (CHU Rouen), and Dr. Béatrice Lannes (CHU Strasbourg).

Funding

This work was supported by a grant from the Fondation de l’Avenir to Matthieu Peyre (Project No. AP-RM-21015).

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Authors and Affiliations

  1. Sorbonne University, Paris Brain Institute, CRICM INSERM U1127 CNRS UMR 7225, APHP, 75013, Paris, France

    Julien Boetto, Isabelle Plu, Yohan Ducos, Antoine Blouin, Yu Teranishi, Claude-Alain Maurage, Sara Bizzotto, Michel Kalamarides & Matthieu Peyre

  2. Department of Neurosurgery, Gui de Chauliac Hospital, CHU de Montpellier, 34090, Montpellier, France

    Julien Boetto

  3. Department of Neuropathology, AP-HP, Hôpital Pitié Salpétrière, 75013, Paris, France

    Isabelle Plu

  4. Department of Neurosurgery, APHP, Hopital Pitié Salpêtrière, 47-91 Bvd de l’Hopital, 75013, Paris, France

    Michel Kalamarides & Matthieu Peyre

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  1. Julien Boetto
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Consortia

The Brainbank Neuro-CEB Neuropathology Network

  • Franck Letournel
  • , Marie-Laure Martin-Négrier
  • , Maxime Faisant
  • , Catherine Godfraind
  • , Claude-Alain Maurage
  • , Vincent Deramecourt
  • , Mathilde Duchesne
  • , David Meyronnet
  • , Clémence Delteil
  • , Valérie Rigau
  • , Fanny Vandenbos-Burel
  • , Danielle Seilhean
  • , Susana Boluda
  • , Isabelle Plu
  • , Dan Christian Chiforeanu
  • , Florent Marguet
  •  & Béatrice Lannes

Corresponding author

Correspondence to Matthieu Peyre.

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The members of The Brainbank Neuro-CEB Neuropathology Network are listed in Acknowledgements.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 23 kb)

Supplementary Table 1: Main metrics after sequencing for the whole cohort. (XLSX 14 kb)

Supplementary Table 2: List of the 29 genes targeted for targeted exome sequencing. (XLSX 9 kb)

401_2023_2635_MOESM4_ESM.xlsx

Supplementary Table 3: Table of the 30 variants remaining after variant calling and exclusion of non-functionally significant variants. Algorithms: MT: Mutect2; LF: Samtools1-10 mpileup; ST: Strelka 2.9.10 (see Supplementary methods). (XLSX 14 kb)

401_2023_2635_MOESM5_ESM.xlsx

Supplementary Table 4: Table of the results of the sequencing on the main hotspots in meningioma-driver genes. (XLSX 38 kb)

401_2023_2635_MOESM6_ESM.tiff

Supplementary Fig. 1. Histological analysis of arachnoid (a, b, c) and dura mater (d, e, f) samples. Whole samples for arachnoid and dura mater are displayed in a. and b. respectively (scale bars 2 mm), revealing the global architecture of each tissue. Arachnoid tissue presented a majority of areas with typical meningothelial architecture (b., scale bar 100 μm) but also several blood vessels (asterisks in c., scale bar 100 μm). Dura mater samples presented with typical collagen fibers (e. scale bar 100 μm) but occasionally displayed small inclusions of arachnoid cells with round nuclei and clear cytoplasm (black arrow heads in f., scale bar 100 μm). (TIFF 33631 kb)

401_2023_2635_MOESM7_ESM.tiff

Supplementary Fig. 2. NF2 and TRAF7 mutations in normal meninges detected by ddPCR. Two dimensional ddPCR plots of TRAF7-mutant meningeal samples and meningioma controls. The wild type and mutant droplets for each mutation are displayed on the X and Y axis, respectively. For each sample, the number of mutant and wild type droplets are indicated at the top left and bottom right corners, respectively. (TIFF 35160 kb)

Supplementary Fig. 3. Heatmap of the main chromosomal gain and loss in the whole cohort. (TIFF 35160 kb)

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Boetto, J., Plu, I., Ducos, Y. et al. Normal meninges harbor oncogenic somatic mutations in meningioma-driver genes. Acta Neuropathol 146, 833–835 (2023). https://doi.org/10.1007/s00401-023-02635-4

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  • DOI: https://doi.org/10.1007/s00401-023-02635-4

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