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Decreased dystrophin expression and elevated dystrophin-targeting miRNAs in anti-HMGCR immune-mediated necrotizing myopathy

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Data availability

All data supporting the findings of this study are available within the paper and the supplementary online information.

References

  1. Allenbach Y, Mammen AL, Benveniste O, Stenzel W, Allenbach Y, Amato A et al (2018) 224th ENMC international workshop: Clinico-sero-pathological classification of immune-mediated necrotizing myopathies. Neuromuscul Disord 28:87–99. https://doi.org/10.1016/j.nmd.2017.09.016

    Article  PubMed  Google Scholar 

  2. Fiorillo AA, Heier CR, Novak JS, Tully CB, Brown KJ, Uaesoontrachoon K et al (2015) TNF-alpha-Induced microRNAs control dystrophin expression in becker muscular dystrophy. Cell Rep 12:1678–1690. https://doi.org/10.1016/j.celrep.2015.07.066

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Kinder TB, Heier CR, Tully CB, Van der Muelen JH, Hoffman EP, Nagaraju K et al (2020) Muscle weakness in myositis: microRNA-mediated dystrophin reduction in a myositis mouse model and human muscle biopsies. Arthritis Rheumatol 72:1170–1183. https://doi.org/10.1002/art.41215

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Kishi T, Rider LG, Pak K, Barillas-Arias L, Henrickson M, McCarthy PL et al (2017) Association of Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme a reductase autoantibodies with drb1*07:01 and severe myositis in juvenile myositis patients: HMGCR autoantibodies in juvenile myositis. Arthritis Care Res (Hoboken) 69:1088–1094. https://doi.org/10.1002/acr.23113

    Article  CAS  PubMed  Google Scholar 

  5. Meyer A, Troyanov Y, Drouin J, Oligny-Longpre G, Landon-Cardinal O, Hoa S et al (2020) Statin-induced anti-HMGCR myopathy: successful therapeutic strategies for corticosteroid-free remission in 55 patients. Arthritis Res Ther 22:5. https://doi.org/10.1186/s13075-019-2093-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Mohassel P, Mammen AL (2018) Anti-HMGCR myopathy. J Neuromuscul Dis 5:11–20. https://doi.org/10.3233/JND-170282

    Article  PubMed  PubMed Central  Google Scholar 

  7. Simard LR, Viel J, Lambert M, Paradis G, Levy E, Delvin EE et al (2004) The Delta>15 Kb deletion French Canadian founder mutation in familial hypercholesterolemia: rapid polymerase chain reaction-based diagnostic assay and prevalence in Quebec. Clin Genet 65:202–208. https://doi.org/10.1111/j.0009-9163.2004.00223.x

    Article  CAS  PubMed  Google Scholar 

  8. Wang CH, Liang WC (2023) Pediatric immune-mediated necrotizing myopathy. Front Neurol 14:1123380. https://doi.org/10.3389/fneur.2023.1123380

    Article  PubMed  PubMed Central  Google Scholar 

  9. Yu L, Qiu S, Genest J Jr (1996) Abnormal regulation of the LDL-R and HMG CoA reductase genes in subjects with familial hypercholesterolemia with the “French Canadian mutation.” Atherosclerosis 124:103–117. https://doi.org/10.1016/0021-9150(96)05828-5

    Article  CAS  PubMed  Google Scholar 

  10. Zhou M, Cheng X, Zhu W, Jiang J, Zhu S, Wu X et al (2022) Activation of cGAS-STING pathway - A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy. J Clin Lab Anal 36:e24631. https://doi.org/10.1002/jcla.24631

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

The authors wish to thank Carl Faille and Hélène Tanguay for histotechnical expertise.

Funding

This study was supported by a research grant from Canadian Institutes of Health Research (#PJT-156408).

Author information

Authors and Affiliations

  1. Division of Rheumatology, CHU de Québec-Université Laval, Québec, Québec, Canada

    Maude B. Marmen

  2. CHU Sainte-Justine Research Centre, Montréal, Québec, Canada

    Zakaria Orfi, Junio Dort & Nicolas A. Dumont

  3. Department of Pharmacology and Physiology, Université de Montréal, Montréal, Québec, Canada

    Zakaria Orfi & Junio Dort

  4. Division of Pediatric Rheumatology, CHU de Québec-Université Laval, Québec, Québec, Canada

    Jean-Philippe Proulx-Gauthier

  5. Division of Pediatric Neurology, CHU de Québec-Université Laval, Québec, Québec, Canada

    Nicolas Chrestian

  6. School of Rehabilitation, Université de Montréal, Montréal, Québec, Canada

    Nicolas A. Dumont

  7. Division of Pathology, Department of Pathology and Cell Biology, CHU Sainte-Justine, Université de Montréal, 3175 Chemin de La Côte-Sainte-Catherine, Montréal, Québec, H3T 1C5, Canada

    Benjamin Ellezam

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  1. Maude B. Marmen
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  2. Zakaria Orfi
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Corresponding author

Correspondence to Benjamin Ellezam.

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None of the authors have conflicts of interest to disclose.

Ethical approval

This study was approved by the institutional review board of CHU Sainte-Justine (#2023–4998).

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Marmen, M.B., Orfi, Z., Dort, J. et al. Decreased dystrophin expression and elevated dystrophin-targeting miRNAs in anti-HMGCR immune-mediated necrotizing myopathy. Acta Neuropathol 146, 655–658 (2023). https://doi.org/10.1007/s00401-023-02619-4

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  • DOI: https://doi.org/10.1007/s00401-023-02619-4

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