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Neuroglial stem cell-derived inflammatory pseudotumor (n-SCIPT): clinicopathologic characterization of a novel lesion of the lumbosacral spinal cord and nerve roots following intrathecal allogeneic stem cell intervention

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Acknowledgements

The authors wish to thank the patient, who gave informed consent for publication of this study, for his invaluable contributions to neuroscience research. The authors also wish to thank Dr. Arie Perry for thoughtful discussions during initial work-up of the patient’s biopsy, and clinic nurse Denise Feng, RN, for her assistance and follow-up care of the patient. This work was supported by the Sandler and William K. Bowes Jr Foundations, a National Institute of Neurological Disorders and Stroke award (K08NS096117); and an American Academy of Neurology Clinical Research Training Scholarship (P0534134).

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Author notes

  1. Emily A. Sloan, Paul J. Sampognaro, Marta Margeta and John W. Engstrom made equal contributions.

Authors and Affiliations

  1. Department of Pathology, University of California, San Francisco, Box 0511, San Francisco, USA

    Emily A. Sloan, Andrew W. Bollen, David A. Solomon & Marta Margeta

  2. Department of Neurology, University of California, San Francisco, San Francisco, USA

    Paul J. Sampognaro, Prashanth S. Ramachandran, Michael R. Wilson, Arnold R. Kriegstein & John W. Engstrom

  3. Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, USA

    Paul J. Sampognaro, Prashanth S. Ramachandran, Michael R. Wilson, Arnold R. Kriegstein & John W. Engstrom

  4. Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, USA

    Jacqueline C. Junn & Cynthia Chin

  5. Department of Neurological Surgery, University of California, San Francisco, San Francisco, USA

    Line Jacques

  6. Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, USA

    Joseph L. DeRisi

  7. Chan Zuckerberg Biohub, San Francisco, USA

    Joseph L. DeRisi

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  1. Emily A. Sloan
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Corresponding author

Correspondence to Marta Margeta.

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Conflict of interest

ARK is a co-founder and member of the board of Neurona Therapeutics. Other authors have no conflicts of interest relevant to this article.

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Informed consent was obtained from the individual participant described in the study.

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401_2019_2089_MOESM1_ESM.tif

Supplementary Figure S1. Additional radiologic evaluation of progressive S1 nerve root thickening. a-b Sagittal serial MR images obtained approximately 16 months apart show progressive diffuse thickening of all the cauda equina nerve roots with effacement of the CSF space (arrows). c-d Positron emission computed topography (PET-CT) imaging shows increased uptake in the lumbosacral spinal cord, cauda equina, and associated nerve roots. (TIFF 4187 kb)

401_2019_2089_MOESM2_ESM.tif

Supplementary Figure S2. Additional characterization of aberrant neuroglial tissue. a H&E section demonstrating nerve root (lower left) encased by aberrant neuroglial tissue; mitoses were not identified. The glial component shows diffuse positivity for ATRX (b) and scattered positivity for OLIG2 (c). d The Ki-67 labeling index is less than 1%. Scale bar = 50 µm for all panels. (TIFF 9122 kb)

401_2019_2089_MOESM3_ESM.tif

Supplementary Figure S3. Immunohistochemical characterization of the inflammatory infiltrate in aberrant neuroglial tissue. a H&E sections from deeper within the tissue block showed scattered and clustered small inflammatory cells. b The vast majority of inflammatory cells are T lymphocytes, as identified by CD3 immunoreactivity. c B lymphocytes were essentially absent, as demonstrated by immunohistochemistry for CD20. d CD68 highlights scattered macrophages and microglia within the neuroglial tissue. Scale bar = 50 µm for all panels. (TIFF 9123 kb)

Supplementary material 4 (Tables S1, S3 and S4) (DOCX 22 kb)

Supplementary material 5 (Table S2) (XLSX 21 kb)

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Sloan, E.A., Sampognaro, P.J., Junn, J.C. et al. Neuroglial stem cell-derived inflammatory pseudotumor (n-SCIPT): clinicopathologic characterization of a novel lesion of the lumbosacral spinal cord and nerve roots following intrathecal allogeneic stem cell intervention. Acta Neuropathol 138, 1103–1106 (2019). https://doi.org/10.1007/s00401-019-02089-7

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