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Nanoparticles prepared by self-assembly of Chitosan and poly-γ-glutamic acid

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Abstract

The present paper describes the preparation and characterization of novel biodegradable nanoparticles based on self-assembly of poly-gamma-glutamic acid (γ-PGA) and chitosan (CH). The nanosystems were stable in aqueous media at low pH conditions. Solubility of the systems was determined by turbidity measurements. Surface charge and mobility were measured electrophoretically. The particle size and the size distribution of the polyelectrolyte complexes were identified by dynamic light scattering and transmission electron microscopy (TEM). It was found that the size and size distribution of the nanosystems depends on the concentrations of γ-PGA and CH solutions and their ratio as well as on the pH of the mixture and the order of addition. The diameter of individual particles was in the range of 20–285 nm measured by TEM, and the average hydrodynamic diameters were between 150 and 330 nm. These biodegradable, self-assembling stable nanocomplexes might be useful for several biomedical applications.

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Acknowledgment

This work was supported by RET (Grant of the Regional University Knowledge Center) contract number (RET-06/432/2004) and by ElizaNor Polymer LLC, USA.

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Authors and Affiliations

  1. Department of Colloid and Environmental Chemistry, University of Debrecen, 4010, Debrecen, Hungary

    Istvan Hajdu, Magdolna Bodnár & János Borbély

  2. Materials Structure and Modeling Research Group of the Hungarian Academy of Sciences, Budapest University of Technology and Economics, 1521, Budapest, Hungary

    Genovéva Filipcsei & Miklós Zrínyi

  3. ElizaNor Polymer LLC, Princeton Junction, NJ, 08550, USA

    John F. Hartmann

  4. Department of Solid State Physics, University of Debrecen, 4010, Debrecen, Hungary

    Lajos Daróczi

  5. BBS Nanotechnology Ltd., 4225, Debrecen 16, P.O.Box 12, Hungary

    János Borbély

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  1. Istvan Hajdu
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  2. Magdolna Bodnár
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  3. Genovéva Filipcsei
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  4. John F. Hartmann
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  5. Lajos Daróczi
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  6. Miklós Zrínyi
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  7. János Borbély
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Correspondence to János Borbély.

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Hajdu, I., Bodnár, M., Filipcsei, G. et al. Nanoparticles prepared by self-assembly of Chitosan and poly-γ-glutamic acid. Colloid Polym Sci 286, 343–350 (2008). https://doi.org/10.1007/s00396-007-1785-7

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  • DOI: https://doi.org/10.1007/s00396-007-1785-7

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