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Presence of endothelial colony-forming cells is associated with reduced microvascular obstruction limiting infarct size and left ventricular remodelling in patients with acute myocardial infarction

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Abstract

Endothelial colony-forming cells (ECFCs) are known to increase after acute myocardial infarction (AMI). We examined whether the presence of ECFCs is associated with preserved microvascular integrity in the myocardium at risk by reducing microvascular obstruction (MVO). We enrolled 88 patients with a first ST elevation AMI. ECFC colonies and circulating progenitor cells were characterized at admission. MVO was evaluated at 5 days and infarct size at 5 days and at 6-month follow-up by magnetic resonance imaging. ECFC colonies were detected in 40 patients (ECFCpos patients). At 5 days, MVO was of greater magnitude in ECFCneg versus ECFCpos patients (7.7 ± 5.3 vs. 3.2 ± 5%, p = 0.0002). At 6 months, in ECFCpos patients, there was a greater reduction in infarct size (−32.4 ± 33 vs. −12.8 ± 24%; p = 0.003) and a significant improvement in left ventricular (LV) volumes and ejection fraction. Level of circulating CD34+/VEGF-R2+ cells was correlated with the number of ECFC colonies (r = 0.54, p < 0.001) and relative change in infarct size (r = 0.71, p < 0.0001). The results showed that the presence of ECFC colonies is associated with reduced MVO after AMI, leading to reduced infarct size and less LV remodelling and can be considered a marker of preserved microvascular integrity in AMI patients.

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Acknowledgments

This study was financed by the French National Programme for Hospital Research (Programme hospitalier de rechercheclinique, PHRC), a state-sponsored programme for funding research.

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Authors and Affiliations

  1. Service de Cardiologie, CHU Besançon, IFR 133, EA 3920, University of Franche-Comté, Besançon, France

    Nicolas Meneveau, Marie-France Séronde, Romain Chopard, François Schiele & Jean-Pierre Bassand

  2. INSERM U645, Etablissement Français du Sang Bourgogne Franche-Comté, IFR133, University of Franche-Comté, Besançon, France

    Frédéric Deschaseaux & Pierre Tiberghien

  3. Service de Radiologie, CHU Besançon, University of Franche-Comté, Besançon, France

    Jérome Jehl

  4. Laboratoire de Pharmacologie Clinique et Toxicologie, CHU Besançon, IFR 133, EA 3920, University of Franche-Comté, Besançon, France

    Jean-Pierre Kantelip & Siamak Davani

  5. Department of Cardiology EA3920, University Hospital Jean Minjoz, 25000, Besançon, France

    Nicolas Meneveau

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  1. Nicolas Meneveau
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N. Meneveau and F. Deschaseaux contributed equally to this work.

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Meneveau, N., Deschaseaux, F., Séronde, MF. et al. Presence of endothelial colony-forming cells is associated with reduced microvascular obstruction limiting infarct size and left ventricular remodelling in patients with acute myocardial infarction. Basic Res Cardiol 106, 1397–1410 (2011). https://doi.org/10.1007/s00395-011-0220-x

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