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Mixed pineal mature teratoma and germinoma in two brothers of the fraternal triplets

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Abstract

Introduction

Intracranial teratomas are rare germ cell neoplasms that contain tissues derived from all three germ cell layers and most commonly occurring during childhood. This is the first report of pineal region mixed mature teratoma and germinoma in two fraternal brothers of fraternal triplets.

Case presentation

We report the case of a mixed mature teratoma and germinoma of the pineal region in two brothers of fraternal triplets. Older brother was initially diagnosed at the age of 11 years with the pure teratoma of the pineal region but the review of the pathology 3 years after initial surgery revealed the mixed mature teratoma with 5% germinomatous component. The younger brother was diagnosed at the age of 13 years with the mixed mature teratoma with 10% germinomatous component tumor of the pineal region. Younger brother has been treated with adjuvant chemo-radiotherapy and older brother was treated without adjuvant therapy. Both brothers had no recurrence.

Conclusion

Pineal mature teratomas have a good prognosis, in contrast to their immature or mixed counterparts. A rigorous histological examination of the tumor samples is mandatory, in order to not omit a mixed contingent within the tumor.

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Authors and Affiliations

  1. Division of Neurosurgery, Ann and Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA

    Gordan Grahovac & Tord Alden

  2. Department of Pathology, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 60611, USA

    Wadhwani Nitin

Authors
  1. Gordan Grahovac
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  2. Tord Alden
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  3. Wadhwani Nitin
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Correspondence to Gordan Grahovac.

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The authors declare that they have no conflict of interest.

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Grahovac, G., Alden, T. & Nitin, W. Mixed pineal mature teratoma and germinoma in two brothers of the fraternal triplets. Childs Nerv Syst 33, 859–863 (2017). https://doi.org/10.1007/s00381-017-3349-6

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  • DOI: https://doi.org/10.1007/s00381-017-3349-6

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