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Primary intracranial germ-cell tumors in adults: a practical review

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Abstract

Primary intracranial germ-cell tumors are rare tumors primarily of adolescence, and literature on this disease in adults is scarce. The available evidence on intracranial germ-cell tumors is reviewed with a focus on adult patients whenever possible, and used to make suggestions for diagnosis and treatment. Diagnostic and treatment algorithms were developed to provide an evidence-based backbone to base treatment on in adult patients with a (suspected) primary intracranial germ-cell tumor.

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  The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Department of Neuro-Oncology, Daniel den Hoed Cancer Center, Erasmus University Medical Center, P O Box 5201, 3008 AE, Rotterdam, The Netherlands

    Jacoline E. C. Bromberg

  2. Department of Radiation-Oncology (MAASTRO), GROW (School for Oncology), Maastricht University Medical Centre, Maastricht, The Netherlands

    Brigitta G. Baumert

  3. Department of Medical Oncology, Utrecht University Medical Center, Utrecht, The Netherlands

    Filip de Vos

  4. Department of Neurology, Radboud University Medical Centre, Nijmegen, The Netherlands

    Johanna M. M. Gijtenbeek

  5. Department of Neurosurgery, Radboud University Medical Center, Nijmegen, The Netherlands

    Erkan Kurt

  6. Department of Medical Oncology, Academic Medical Centre, Amsterdam, The Netherlands

    Anneke M. Westermann

  7. Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    Pieter Wesseling

  8. VU University Medical Center, Amsterdam, The Netherlands

    Pieter Wesseling

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  1. Jacoline E. C. Bromberg
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Correspondence to Jacoline E. C. Bromberg.

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Bromberg, J.E.C., Baumert, B.G., de Vos, F. et al. Primary intracranial germ-cell tumors in adults: a practical review. J Neurooncol 113, 175–183 (2013). https://doi.org/10.1007/s11060-013-1114-6

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  • DOI: https://doi.org/10.1007/s11060-013-1114-6

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