Abstract
The study aimed to identify factors related to bone mineral density (BMD) among older patients with heart failure (HF). A total of 70 consecutive patients with HF aged 65 years or older who were admitted to an acute hospital due to worsening condition were enrolled before discharge. BMD of the femoral neck was evaluated using the DEXA method. Physical function, as well as echocardiographic and laboratory findings including biomarker of HF severity were collected. Bivariate and multiple regression analyses were employed to determine the association between BMD and the clinical variables. Bivariate analysis determined that age, grip strength, walking speed, serum albumin, and N-terminal pro B-type natriuretic peptide (NT-proBNP) were significantly correlated with BMD (P < 0.01), whereas other clinical parameters were not. The multiple regression analysis identified NT-proBNP as an independent related factor for BMD after adjusting with confounding clinical variables. NT-proBNP was independently related to BMD among older patients with HF. Our results suggest the inclusion of bone fracture prevention strategies in disease management programs, especially for older patients with HF.
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This work was supported by JSPS KAKENHI grant no. 16K09460. None of the work in this article has been presented at a conference or in any other publications.
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Hideo Izawa has received grant support through his institution from Takeda, Shionogi, Dainippon-Sumitomo, Otsuka, Pfizer, and Daiichi-Sankyo and honoraria for lectures from Otsuka and Daiichi-Sankyo.
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Kono, Y., Izawa, H., Aoyagi, Y. et al. Impact of heart failure severity on bone mineral density among older patients with heart failure. Heart Vessels 36, 1856–1860 (2021). https://doi.org/10.1007/s00380-021-01884-1
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DOI: https://doi.org/10.1007/s00380-021-01884-1