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Prevalence and predictors of nocturnal polyuria in females with overactive bladder syndrome

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Abstract

Purpose

To describe the prevalence and predictors of nocturnal polyuria (NP) in women with overactive bladder syndrome (OAB).

Methods

Between July 2009 and January 2018, women with OAB were enrolled. NP was defined when the nocturnal polyuria index (NPI) (nighttime voided volume over 24-h voided volume) was > 33% (NPI33) in women ≥ 65 years-old and > 20% (NPI20) in women < 65 years old. Repeated analysis was also performed for NP defined by the NPI33 definition at all ages.

Results

A total of 1071 women with OAB were analyzed. The overall prevalence of NP was 30% (319/1071), with the highest prevalence in women in the perimenopausal period (46–50 years old), while NP was diagnosed by age-dependent NPI. The overall prevalence of NP was 12% (128/1071), with an increasing trend with increasing age, while NP was diagnosed by the NPI33 definition only. Daytime frequency and nocturia episodes were both predictors for NP in both definitions. Receiver operating characteristic curve analysis revealed that more than 5 nocturia episodes noted in the 3-day bladder diary were an optimal cutoff value to predict nocturnal polyuria [(sensitivity = 85.6%, specificity = 61.0%; area = 0.80, 95% CI 0.77–0.82) and (sensitivity = 88.3%, specificity = 65.9%; area = 0.83, 95% CI 0.80–0.85), respectively, in the two definitions].

Conclusions

NP is common in women with OAB, especially in women with more than 5 nocturia episodes in their 3-day bladder diaries, and adjuvant therapy for better treatment efficacy is needed.

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Availability of data and material

The datasets analyzed during the study are available from the corresponding author on reasonable request.

Code availability

Not applicable.

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Acknowledgements

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, National Taiwan University College of Medicine and Hospital, No. 8, Chung-Shan South Road, Taipei, 100, Taiwan

    Pei-Chi Wu & Ho-Hsiung Lin

  2. Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao, New Taipei, Taiwan

    Sheng-Mou Hsiao & Ho-Hsiung Lin

  3. Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Taoyuan, Taiwan

    Sheng-Mou Hsiao

Authors
  1. Pei-Chi Wu
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  2. Sheng-Mou Hsiao
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  3. Ho-Hsiung Lin
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Contributions

P-CW: manuscript writing. S-MH: data collection and data analysis. H-HL: protocol development and manuscript editing.

Corresponding author

Correspondence to Ho-Hsiung Lin.

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The authors declare no competing interests.

Ethical approval

This study received approval from the Research Ethics Committee of the National Taiwan University Hospital (ID No. 201810091RIND).

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Not applicable for the retrospective study.

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Wu, PC., Hsiao, SM. & Lin, HH. Prevalence and predictors of nocturnal polyuria in females with overactive bladder syndrome. World J Urol 40, 519–527 (2022). https://doi.org/10.1007/s00345-021-03865-5

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  • DOI: https://doi.org/10.1007/s00345-021-03865-5

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