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Cell death in development, maintenance, and diseases of the nervous system

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Abstract

Cell death, be it of neurons or glial cells, marks the development of the nervous system. Albeit relatively less so than in tissues such as the gut, cell death is also a feature of nervous system homeostasis—especially in context of adult neurogenesis. Finally, cell death is commonplace in acute brain injuries, chronic neurodegenerative diseases, and in some central nervous system tumors such as glioblastoma. Recent studies are enumerating the various molecular modalities involved in the execution of cells. Intimately linked with cell death are mechanisms of disposal that remove the dead cell and bring about a tissue-level response. Heretofore, the association between these methods of dying and physiological or pathological responses has remained nebulous. It is envisioned that careful cartography of death and disposal may reveal novel understandings of disease states and chart new therapeutic strategies in the near future.

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  1. Sourav Ghosh and Carla V. Rothlin contributed equally to this work.

Authors and Affiliations

  1. Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA

    Maria E. Mercau, Siraj Patwa & Carla V. Rothlin

  2. Department of Translational Molecular Pathology, Division of Pathology-Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Krishna P. L. Bhat

  3. Department of Neurology, School of Medicine, Yale University, New Haven, CT, USA

    Sourav Ghosh

  4. Department of Pharmacology, School of Medicine, Yale University, New Haven, CT, USA

    Sourav Ghosh & Carla V. Rothlin

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Correspondence to Carla V. Rothlin.

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Competing interests

C.V.R is a scientific founder and member of the Scientific Advisory Board (SAB) of Surface Oncology, a member of Janssen Immunology SAB, and a consultant for the Roche Immunology Incubator. C.V.R and S.G. have received grant support from Mirati Therapeutics. All other authors declare no competing interests.

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This article is a contribution to the special issue on: Neuroimmune Interactions in Health and Disease - Guest Editors: David Hafler & Lauren Sansing

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Mercau, M.E., Patwa, S., Bhat, K.P.L. et al. Cell death in development, maintenance, and diseases of the nervous system. Semin Immunopathol 44, 725–738 (2022). https://doi.org/10.1007/s00281-022-00938-4

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