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Adding Short to Left Gastric Artery Embolization for the Treatment of Obesity: Safety and Effectiveness

  • Clinical Investigation
  • Embolisation (arterial)
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

Purpose

This study assessed the safety and effectiveness of a technical modification that involves adding short gastric artery (SGA) embolization to left gastric artery (LGA) embolization.

Material and Methods

This retrospective single-center study analyzed twenty obese patients (median age of 53.5 (30–73)) who were not eligible for bariatric surgery and underwent bariatric embolization with 300–500-µm microspheres in addition to a lifestyle counseling program between March 2021 and July 2022. Eight patients had LGA + SGA embolization, and twelve had LGA embolization alone. The primary outcome measure was total body weight loss (TBWL) at 6 months in the SGA + LGA and the LGA-only cohorts. Safety was assessed, defined as the 30-day adverse events rate according to the SIR classification.

Results

The mean 6-month post-embolization TBWL in the SGA + LGA cohort was 7.3 kg (95%CI 2.1–12.4; p = .01) and 4.1 kg (95%CI 0.4–8.6; p = 0.034) in the LGA-only cohort (mean difference − 3.1 kg ± 2.8; 95%CI (− 9.1–2.8); p = .28). The mean 6-month post-embolization TBWL in the entire cohort was 5.3 kg (p < .01). The rate of complications was similar between the two groups.

Conclusion

Combined SGA and LGA embolization is safe and effective to treat obesity. Larger studies are needed to determine whether SGA + LGA embolization results in more significant weight loss than LGA embolization alone.

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Data Availability

The datasets generated or analyzed during the study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Department of Radiology, Hôpital Beaujon, APHP.Nord, Université Paris Cité, Clichy, France

    Raphaël di Giuseppe, Valérie Vilgrain, Maxime Ronot & Lorenzo Garzelli

  2. Department of Endocrinology-Diabetology-Nutrition, Hôpital Bichat, APHP.Nord, Université Paris Cité, Paris, France

    Boris Hansel & Jeremy Puyraimond Zemmour

  3. Department of Medical Imaging, Cayenne Hospital Centre, Cayenne, French Guiana

    Lorenzo Garzelli

Authors
  1. Raphaël di Giuseppe
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  2. Boris Hansel
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  3. Jeremy Puyraimond Zemmour
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  4. Valérie Vilgrain
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  5. Maxime Ronot
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  6. Lorenzo Garzelli
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Contributions

LG helped in conceptualization. RdG helped in data curation. LG and MR helped in formal analysis. Funding acquisition: Not concerned. Investigation: Not concerned. LG and MR helped in methodology. Project administration: Not concerned. Resources: Not concerned. Software: Not concerned. LG and MR worked in supervision. LG helped in validation. Visualization: Not concerned. RdG contributed to writing—original draft. LG, VV, BH, JPZ, and MR contributed to writing—review and editing.

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Correspondence to Lorenzo Garzelli.

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di Giuseppe, R., Hansel, B., Puyraimond Zemmour, J. et al. Adding Short to Left Gastric Artery Embolization for the Treatment of Obesity: Safety and Effectiveness. Cardiovasc Intervent Radiol (2024). https://doi.org/10.1007/s00270-024-03702-3

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  • DOI: https://doi.org/10.1007/s00270-024-03702-3

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