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Pharmacokinetics and Histopathological Findings of Chemoembolization Using Cisplatin Powder Mixed with Degradable Starch Microspheres in a Rabbit Liver Tumor Model

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Abstract

Purpose

The purpose of this study is to evaluate the pharmacokinetics and histopathological findings of transarterial chemoembolization (TACE) using cisplatin powder mixed with degradable starch microspheres (DSM) (Cis/DSM-TACE) compared with cisplatin arterial infusion (Cis-AI).

Materials and Methods

Eighteen rabbits with VX2 liver tumors were divided into two groups: Cis/DSM-TACE (n = 9) and Cis-AI (n = 9) groups. In the Cis/DSM-TACE group, a mixture of cisplatin powder and DSM was injected until stasis of hepatic arterial flow was achieved. In the Cis-AI group, cisplatin solution was infused.

Results

The platinum concentrations in VX2 tumors in the Cis/DSM-TACE group at 24 and 72 h were significantly elevated compared with those in the Cis-AI group (P = .016 and .019, respectively). There were no significant differences in the platinum concentrations in plasma. Histopathological examination revealed the presence of several microspheres inside the tumors at 1 h, which completely disappeared at 24 h. Tumor cell apoptosis at 1 h in the Cis/DSM-TACE group was more frequently observed compared with that in the Cis-AI group (P = .006).

Conclusions

TACE using cisplatin powder mixed with DSM provides a higher drug concentration in tumors, thereby achieving stronger antitumor effects compared with arterial infusion of cisplatin solution.

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Acknowledgements

We thank Ms. Marian Pahud for advice in submitting this article. This work was partially supported by Grant-in-Aid for Scientific Research (C), 26461868, and Nara Medical University Grant-in-Aid for Collaborative Research Projects.

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Authors and Affiliations

  1. Department of Radiology, IVR CenterNara Medical University, 840 Shijo-cho, Kashihara, 634-8522, Japan

    Takeshi Sato, Toshihiro Tanaka, Hideyuki Nishiofuku, Yasushi Fukuoka, Tetsuya Masada, Shota Tatsumoto & Kimihiko Kichikawa

  2. Department of Radiology, South Nara General Medical Center, Oyodo, Japan

    Hiroshi Sakaguchi

  3. Department of Radiology, Diagnostic Imaging Center, Kashihara, Japan

    Nagaaki Marugami & Toshiko Hirai

  4. Department of Diagnostic Pathology, Nara Medical University, Kashihara, Japan

    Masato Takano & Chiho Ohbayashi

  5. Department of Surgery, Nara Medical University, Kashihara, Japan

    Ichiro Yamato & Masayuki Sho

Authors
  1. Takeshi Sato
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  2. Toshihiro Tanaka
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  3. Hideyuki Nishiofuku
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  4. Yasushi Fukuoka
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  7. Shota Tatsumoto
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  9. Masato Takano
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  10. Ichiro Yamato
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  11. Masayuki Sho
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  12. Chiho Ohbayashi
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  13. Toshiko Hirai
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  14. Kimihiko Kichikawa
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Corresponding author

Correspondence to Toshihiro Tanaka.

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All authors have no conflicts of interest and financial disclosures to declare.

Research Involving Animal and Human Rights

All applicable institutional and/or national guidelines for the care and use of animals were followed.

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Sato, T., Tanaka, T., Nishiofuku, H. et al. Pharmacokinetics and Histopathological Findings of Chemoembolization Using Cisplatin Powder Mixed with Degradable Starch Microspheres in a Rabbit Liver Tumor Model. Cardiovasc Intervent Radiol 40, 438–444 (2017). https://doi.org/10.1007/s00270-016-1512-1

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  • DOI: https://doi.org/10.1007/s00270-016-1512-1

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