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Extrahepatic Blood Supply to Hepatocellular Carcinoma: Angiographic Demonstration and Transcatheter Arterial Chemoembolization

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Abstract

Purpose

To evaluate the incidence of each extrahepatic collateral pathway to hepatocellular carcinoma (HCC) and to assess technical success rates and complications of transcatheter arterial chemoembolization (TACE) through each collateral.

Methods

We retrospective evaluated extrahepatic collateral pathways to HCC on angiography in 386 procedures on 181 consecutive patients. One hundred and seventy patients had previously undergone TACE. TACE through extrahepatic collaterals using iodized oil and gelatin sponge particles was performed when a catheter was advanced into the tumor-feeding branch to avoid nontarget embolization.

Results

A single collateral was revealed in 275 TACE procedures, two were revealed in 74, and three or more were revealed in 34. Incidences of collateral source to HCC were 83% from the right inferior phrenic artery (IPA), 24% from the cystic artery, 13% from the omental artery, 12% from the right renal capsular artery (RCA) and left IPA, 8% from the right internal mammary artery (IMA) and right intercostal artery (ICA), and 7% from the right inferior adrenal artery (IAA). Technical success rates of TACE were 53% in the right ICA, 70% in the cystic artery, 74% in the omental artery, 93% in the left IPA, 96% in the right IPA, and 100% in the right RCA, right IMA, and right IAA. Complications included skin necrosis after TACE through the right IMA (n = 1), cholecystitis after TACE through the cystic artery (n = 1), and ulcer formation after TACE through the right gastric artery (n = 1), in addition to pleural effusion and basal atelectasis after TACE through the IPA and IMA.

Conclusion

Our study suggests that TACE through extrahepatic collaterals is possible with high success rates, and is also relatively safe.

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Authors and Affiliations

  1. Department of Diagnostic Radiology, Fukuiken Saiseikai Hospital, 7-1, Funabashi, Wadanaka-cho, Fukui, 918-8503, Japan

    Shiro Miyayama, Keiichi Taki, Tetsuya Minami, Yasuji Ryu, Chiharu Ito, Koichi Nakamura & Dai Inoue

  2. Department of Radiology, Kanazawa University, Graduate School of Medical Science, Kanazawa 920-8641, Japan

    Osamu Matsui

  3. Department of Internal Medicine, Fukuiken Saiseikai Hospital, 7-1, Funabashi, Wadanaka-cho Fukui, Fukui, 918-8503, Japan

    Kazuo Notsumata, Daisyu Toya & Nobuyoshi Tanaka

  4. Department of Surgery, Fukuiken Saiseikai Hospital, 7-1, Funabashi, Wadanaka-cho, Fukui, 918-8503, Japan

    Takeshi Mitsui

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  1. Shiro Miyayama
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  2. Osamu Matsui
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  3. Keiichi Taki
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  9. Kazuo Notsumata
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Correspondence to Shiro Miyayama.

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Miyayama, S., Matsui, O., Taki, K. et al. Extrahepatic Blood Supply to Hepatocellular Carcinoma: Angiographic Demonstration and Transcatheter Arterial Chemoembolization. Cardiovasc Intervent Radiol 29, 39–48 (2006). https://doi.org/10.1007/s00270-004-0287-y

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  • DOI: https://doi.org/10.1007/s00270-004-0287-y

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