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Contrast-enhanced CT in the differential diagnosis of bladder cancer and paraganglioma

  • Kidneys, Ureters, Bladder, Retroperitoneum
  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

Purpose

We sought to summarize the value of contrast-enhanced computed tomography (CECT) in the differential diagnosis of bladder paraganglioma (BPG) and bladder cancer.

Methods

The medical records of 19 patients with BPG (13 males, 6 females) and 56 patients with bladder cancer (49 males, 7 females) between November 2007 and June 2023 were retrospectively reviewed. All patients underwent unenhanced and contrast-enhanced CT scanning.

Results

Patient age (46.4 ± 11.1 years vs. 58.6 ± 16.0 years), tumor calcification (1/19 vs. 18/56), stalk (0/19 vs. 10/56), internal vessels (15/19 vs. 19/56) and the enlarged adjacent supplying artery (14/19 vs. 10/56) were significantly different between BPG and bladder cancer (P < 0.05). The CT value in the corticomedullary phase (92.4 ± 16.6 HU vs. 64.0 ± 14.5 HU) and the contrast-enhanced value in the corticomedullary phase (54.5 ± 17.4 HU vs. 28.5 ± 12.8 HU) were significantly greater in BPG patients than in bladder cancer patients (P < 0.001), with corresponding area under the curve values of 0.930 and 0.912, respectively. The optimal cutoff values were 83.2 HU and 38.5 HU, respectively. A CT value > 83.2 HU in the corticomedullary phase and a contrast-enhanced CT value > 38.5 HU in the corticomedullary phase were used to indicate BPG with sensitivities of 78.9% and 89.5%, respectively, and specificities of 94.6% and 75.0%, respectively.

Conclusion

The corticomedullary phase of CECT plays an important role in the preoperative differential diagnosis of BPG and bladder cancer.

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Abbreviations

BPG:

Bladder paraganglioma

CECT:

Contrast-enhanced computed tomography

HU:

Hounsfield unit

GE:

General electric

MRI:

Magnetic resonance imaging

H&E:

Hematoxylin and eosin

SDHB:

Succinate dehydrogenase subunit B

CD 56:

Cell adhesion molecule 56

GATA-3:

GATA binding protein 3

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Author information

Authors and Affiliations

  1. Department of Radiology, Shenzhen Bao’an District Songgang People’s Hospital, Shenzhen, 518105, China

    Jiu-ping Liang

  2. Department of Radiology, Shenzhen Baoan Hospital, Southern Medical University, Shenzhen, 518101, China

    Jiu-ping Liang & Liang Yin

  3. Department of Pathology, The Second Affiliated Hospital, Jinan University, Shenzhen, 518100, China

    Li-kun Gao

  4. Department of Radiology, Provincial Clinical College, Fujian Medical University, Fuzhou, 350001, China

    Lei Yin

  5. Medical Imaging Center, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350001, China

    Wang Ren

  6. Medical Imaging Center, The Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, 529070, China

    Zhi-fa Jin

  7. Department of Radiology, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China

    Li-peng Chen

  8. Department of Radiology, Rehabilitation Hospital of China National Nuclear Corporation, Number 120 Jinjiang Road, Yuelu District, Changsha, 410017, Hunan Province, China

    Yi-yong Liu

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Contributions

Jiu-ping Liang, Liang Yin and Yi-yong Liu designed/performed most of the investigation and data analysis and wrote the manuscript; Li-kun Gao provided pathological assistance; Lei Yin, Wang Ren, Zhi-fa Jin and Li-peng Chen contributed to interpretation of the data and analyses. All of the authors have read and approved the manuscript.

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Correspondence to Yi-yong Liu.

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Liang, Jp., Yin, L., Gao, Lk. et al. Contrast-enhanced CT in the differential diagnosis of bladder cancer and paraganglioma. Abdom Radiol 49, 1584–1592 (2024). https://doi.org/10.1007/s00261-024-04217-8

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