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Image-defined risk factors associated with MYCN oncogene amplification in neuroblastoma and their association with overall survival

  • Kidneys, Ureters, Bladder, Retroperitoneum
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Abdominal Radiology Aims and scope Submit manuscript

Abstract

Objective

The MYCN oncogene is a critical factor in the development and progression of neuroblastoma, and image-defined risk factors (IDRFs) are radiological findings used for the preoperative staging of neuroblastoma. This study aimed to investigate the specific categories of IDRFs associated with MYCN amplification in neuroblastoma and their association with overall survival.

Method

A retrospective analysis was conducted on a cohort of 280 pediatric patients diagnosed with neuroblastoma, utilizing a combination of clinical and radiological data. MYCN amplification status was ascertained through molecular testing, and the assessment of IDRFs was conducted using either contrast-enhanced computed tomography or magnetic resonance imaging. The specific categories of IDRFs associated with MYCN amplification and their association with overall survival were analyzed.

Results

MYCN amplification was identified in 19.6% (55/280) of patients, with the majority of primary lesions located in the abdomen (53/55, 96.4%). Lesions accompanied by MYCN amplification exhibited significantly larger tumor volume and a greater number of IDRFs compared with those without MYCN amplification (P < 0.001). Both univariate and multivariate analyses revealed that coeliac axis/superior mesenteric artery encasement and infiltration of adjacent organs/structures were independently associated with MYCN amplification in abdominal neuroblastoma (P < 0.05). Patients presenting with more than four IDRFs experienced a worse prognosis (P = 0.017), and infiltration of adjacent organs/structures independently correlated with overall survival in abdominal neuroblastoma (P = 0.009).

Conclusion

The IDRFs are closely correlated with the MYCN amplification status and overall survival in neuroblastoma.

Graphical Abstract

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Data availability

The datasets generated or analyzed during the study are available from the corresponding author on reasonable request.

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Acknowledgements

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Funding

The project was funded by Natural Science Foundation of Chongqing ((CSTB)2023NSCQ-BHX0127).

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Authors and Affiliations

  1. Department of Radiology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, No. 136 Zhongshan Road 2, Yuzhong District, Chongqing, 400014, China

    Haoru Wang, Ting Li, Xiaoying Ni, Xin Chen, Ling He & Jinhua Cai

Authors
  1. Haoru Wang
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  2. Ting Li
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  3. Xiaoying Ni
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  4. Xin Chen
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  5. Ling He
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  6. Jinhua Cai
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Contributions

LH, XC, and JC conceived the project. HW, TL, XN, and XC collected the data. HW analyzed the data and wrote the first draft of the manuscript. JC revised this manuscript. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Xin Chen, Ling He or Jinhua Cai.

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Competing interests

The authors declare that they have no competing interests.

Ethics approval and consent to participate

This retrospective study received approval from the Institutional Review Board of Children’s Hospital of Chongqing Medical University, and patient informed consent was waived because this was a retrospective study.

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Not applicable.

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Wang, H., Li, T., Ni, X. et al. Image-defined risk factors associated with MYCN oncogene amplification in neuroblastoma and their association with overall survival. Abdom Radiol (2024). https://doi.org/10.1007/s00261-024-04196-w

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  • DOI: https://doi.org/10.1007/s00261-024-04196-w

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