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Effect of different driver power amplitudes on liver stiffness measurement in pediatric liver MR elastography

  • Hepatobiliary
  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

Purpose

To assess how different driver power amplitudes affect the measurement of liver stiffness in pediatric liver magnetic resonance elastography (MRE).

Methods

From January 2018 to May 2018, pediatric patients (≤ 18 years) who underwent liver MRE with 20% and 56% driver power amplitudes were included in this retrospective study. Region-of-interests (ROIs) were drawn on four stiffness maps to include the largest area of the liver parenchyma. Intraclass correlation coefficients (ICCs) were used to assess agreements for the area, mean, maximum, minimum and standard deviation of liver stiffness between the driver power amplitudes.

Results

128 MRE stiffness maps from 16 patients (M:F = 10:6, median 12.5 years old) were included. On MRE, median ROI areas of liver were 83.1 cm2 (range, 46.9–144.1 cm2) and 63.0 cm2 (range, 5.4–123.4 cm2) for the driver power amplitudes of 20% and 56%, respectively. Median liver stiffness values were 2.3 kPa (range, 1.7–8.0 kPa) and 2.8 kPa (range, 1.7–8.5 kPa). Maximum and minimum liver stiffness values were 5.3 kPa and 1.0 kPa for 20% and 7.8 kPa and 1.1 kPa for 56%. Standard deviation was 0.6 kPa for 20% and 1.0 kPa for 56%. ICC values between the two power amplitudes were 0.33–0.51 for the ROI area and the maximum, minimum and standard deviation values of liver stiffness. The ICC value for liver stiffness was 0.857 (95% confidence interval, 0.760–0.915).

Conclusion

Liver stiffness with two driver power amplitudes on MRE showed good reliability in pediatric patients. Driver power amplitudes need to be optimized according to the pediatric liver size.

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Funding

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Authors and Affiliations

  1. Department of Radiology, the Armed Forces Capital Hospital, Seongnam, Republic of Korea

    Dong-Kyu Kim

  2. Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Republic of Korea

    Dong-Kyu Kim, Haesung Yoon, Kyunghwa Han, Jisoo Kim, Mi-Jung Lee & Hyun Joo Shin

  3. Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

    Seung Kim & Hong Koh

  4. Department of Pediatric Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

    Seok Joo Han

  5. Severance Pediatric Liver Disease Research Group, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

    Haesung Yoon, Jisoo Kim, Mi-Jung Lee, Seung Kim, Hong Koh, Seok Joo Han & Hyun Joo Shin

  6. Department of Radiology, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do, 16995, Republic of Korea

    Hyun Joo Shin

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  1. Dong-Kyu Kim
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  2. Haesung Yoon
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Correspondence to Hyun Joo Shin.

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The Institutional Review Board approved this single-center retrospective study and waived the requirement for informed consent.

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Kim, DK., Yoon, H., Han, K. et al. Effect of different driver power amplitudes on liver stiffness measurement in pediatric liver MR elastography. Abdom Radiol 46, 4729–4735 (2021). https://doi.org/10.1007/s00261-021-03197-3

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  • DOI: https://doi.org/10.1007/s00261-021-03197-3

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