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Hepatic disorders associated with exogenous sex steroids: MR imaging findings

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Abstract

Objective

To describe the MRI findings of the effects of exogenous sex steroids on the liver.

Findings

Estrogens, progesterone and synthetic testosterone are exogenous sex steroids that may result in a variety of liver diseases, including tumour formation and vascular disorders. These hormones are mainly administered in the form of the oral contraceptive pill (OCP) and anabolic steroids. Both are implicated in hepatic adenoma formation. The HNF-1α-mutated and inflammatory adenoma subgroups are more commonly seen in association with the OCP whereas there is an increased incidence of the β-catenin positive subtype with anabolic steroid use. Furthermore, anabolic steroids are associated with hepatocellular carcinoma resulting from malignant transformation of β-catenin positive adenomas. The oral contraceptive pill may also induce vascular disorders within the liver, some of which are related to the prothrombotic effect of the hormones, such as hepatic and portal vein thrombosis. Other hepatic vascular abnormalities resulting from exogenous sex steroids include veno-occlusive disease and peliosis hepatis.

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Acknowledgements

We thank Hock Kua, pathologist, for reviewing the pathological findings in our cases.

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  1. Monash Imaging, Monash Health, Melbourne, Australia

    Cathryn L. Hui & Zhen Jiang Lee

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  1. Cathryn L. Hui
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Correspondence to Cathryn L. Hui.

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Hui, C.L., Lee, Z.J. Hepatic disorders associated with exogenous sex steroids: MR imaging findings. Abdom Radiol 44, 2436–2447 (2019). https://doi.org/10.1007/s00261-019-01941-4

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