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Correlation of 3T multiparametric prostate MRI using prostate imaging reporting and data system (PIRADS) version 2 with biopsy as reference standard

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A Correction to this article was published on 22 November 2019

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Abstract

Objective

To correlate the findings on 3T multiparametric prostate MRI using PIRADS version 2 with prostate biopsy results as the standard of reference.

Materials and methods

134 consecutive treatment naive patients (mean age 64 years, range 41–82 years) underwent MRI-directed prostate biopsy. MRI–TRUS fusion biopsy was used for 77 (77/134 = 57.5%) patients, cognitive fusion for 51 (51/134 = 38.0%) patients, and 6 patients (6/134 = 4.5%) without a target nodule had systematic biopsy only. Out of the 1676 biopsy sites, 237 (237/1676 = 14.1%) were positive on MRI for a PIRADS 3, 4, or 5 nodule. Fifty-eight (58/134, 43.3%) patients had clinically significant prostate cancer (csPCa). The findings on MRI using PIRADS version 2 were correlated with the biopsy results.

Results

The accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of PIRADS ≥ 3 for csPCa were 89%, 76.5%, 89.7%, 31.7%, and 98.4%, respectively. The detection rates of csPCa for PIRADS 3, 4, and 5 nodules were 6.1% (4/66), 33.3% (42/126), and 64.4% (29/45), respectively. MRI did not identify a nodule in 23/1676 (1.4%) biopsy sites that contained csPCa. The MRI reader, biopsy operator, method of fusion biopsy, and zonal location of prostate nodule did not significantly affect the odds of having a biopsy result positive for csPCa.

Conclusion

PIRADS ≥ 3 had high specificity and high negative predictive value for csPCa using biopsy results as the standard of reference. The presence of csPCa from a biopsy site was highly unlikely in the absence of a corresponding PIRADS ≥ 3 nodule.

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Change history

  • 22 November 2019

    Unfortunately the article was published with a spell error in the co-author name “Hassan Maan”. The correct co-author name should be “Hassaan Maan”.

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Authors and Affiliations

  1. Joint Department of Medical Imaging, Toronto General Hospital, University of Toronto, 585 University Ave., Toronto, ON, M5G 2N2, Canada

    Shobhit Mathur, Sangeet Ghai & Hassan Maan

  2. Joint Department of Medical Imaging, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2M9, Canada

    Martin E. O’Malley, Kartik Jhaveri & Boraiah Sreeharsha

  3. Joint Department of Medical Imaging, Mount Sinai Hospital, University of Toronto, 600 University Ave., Toronto, ON, M5G 1X5, Canada

    Myles Margolis & Ants Toi

  4. Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, 155 College St, Toronto, ON, M5T 3M7, Canada

    Lehang Zhong

Authors
  1. Shobhit Mathur
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  2. Martin E. O’Malley
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  7. Lehang Zhong
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  8. Hassan Maan
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  9. Ants Toi
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Contributions

SM: Conceptualization, methodology, data acquisition/analysis, literature review, investigation, validation, writing. MEO and AT: Conceptualization, methodology, data acquisition, clinical studies, literature review, investigation, validation, writing, administration, supervision. SG, KJ, MM, and BS: Conceptualization, methodology, clinical studies, literature review, investigation, validation, writing. LZ: Methodology, literature review, literature review, investigation, data analysis, writing. HM: Conceptualization, methodology, data acquisition/analysis, literature review, investigation, writing.

Corresponding author

Correspondence to Shobhit Mathur.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Waived by institutional Research Ethics Board for this retrospective study.

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Mathur, S., O’Malley, M.E., Ghai, S. et al. Correlation of 3T multiparametric prostate MRI using prostate imaging reporting and data system (PIRADS) version 2 with biopsy as reference standard. Abdom Radiol 44, 252–258 (2019). https://doi.org/10.1007/s00261-018-1696-8

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  • DOI: https://doi.org/10.1007/s00261-018-1696-8

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