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Mucinous cystic neoplasms of the pancreas: high-resolution cross-sectional imaging features with clinico-pathologic correlation

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Abstract

Purpose

To describe the high-resolution cross-sectional (MDCT/MRI) features of mucinous cystic neoplasms (MCN) of the pancreas with clinico-pathologic correlation; to identify imaging predictors of high-grade dysplasia/carcinoma; and to estimate MCN growth rate.

Materials and methods

Thirty-two women (mean age: 46; range, 25–79 years) with resected MCN who underwent preoperative MDCT (n = 20) or MRI (n = 12) examinations over a 14-year period were included. Two radiologists examined retrospectively in consensus the following MDCT/MRI features: MCN location, size/volume, presence of capsule and thickness of the capsule, and presence of mural nodules, enhancing septations, calcifications, chronic pancreatitis, and main pancreatic duct dilation. Imaging features were correlated with clinical symptoms, biochemistry results, and histopathologic features. A univariate model was analyzed for the prediction of high-grade dysplasia/carcinoma. Preoperative MCN growth rate was assessed using a subset of patients with more than one imaging study available (n = 6).

Results

Twenty-five (78%) patients presented with symptoms and 8 (25%) patients had abnormal serum biochemical values. Mean MCN maximum dimensions were 48 × 45 × 45 mm with a mean volume of 169 mL. MCN were located in the tail (n = 18), body (n = 10), neck (n = 2), and (head = 2); 30 (93.5%) MCN were encapsulated, 3 (9%) had calcifications, 4 (12%) showed enhancing nodules, 9 (28%) had enhancing septations, and 5 (15%) had main pancreatic duct dilation. Associated chronic pancreatitis was observed in 4 (12%) patients. The only predictors for high-grade dysplasia/carcinoma were MCN size and volume. Using a cut-off size greater than 8.5 cm, the specificity and sensitivity for high-grade dysplasia/carcinoma were 97 and 60%, respectively (p = 0.003; OR 81, 95% CI 3.9–1655.8). Mean MCN growth rate was estimated at 4.2 mm/year with a doubling time of 8.23 years.

Conclusion

MCN size (> 8.5 cm) and volume are the only features on MDCT/MR imaging that correlate with high-grade dysplasia/carcinoma. The average growth rate for MCNs is slow at approximately 4 mm per year.

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Authors and Affiliations

  1. Division of Abdominal Imaging, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue – Ansin 235, Boston, MA, 02115, USA

    Alejandro Garces-Descovich, Kevin Beker, Alexander Brook, Elena Resnick & Koenraad J. Mortele

  2. Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA

    Manuel Castillo-Angeles

  3. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA

    Shweta Shinagare & Robert M. Najarian

Authors
  1. Alejandro Garces-Descovich
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  2. Kevin Beker
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  3. Manuel Castillo-Angeles
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  4. Alexander Brook
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Correspondence to Alejandro Garces-Descovich.

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Garces-Descovich, A., Beker, K., Castillo-Angeles, M. et al. Mucinous cystic neoplasms of the pancreas: high-resolution cross-sectional imaging features with clinico-pathologic correlation. Abdom Radiol 43, 1413–1422 (2018). https://doi.org/10.1007/s00261-017-1326-x

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