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Patient-specific dosimetry for intracavitary 32P-chromic phosphate colloid therapy of cystic brain tumours

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Abstract

Purpose

32P-chromic phosphate colloid treatments of astrocytoma and craniopharyngioma cystic brain tumours in paediatric patients are conventionally based on a sphere model under the assumption of uniform uptake. The aims of this study were to determine the distribution of the absorbed dose delivered by 32P on a patient-specific basis and to evaluate the accuracy with which this can be predicted from a pretherapy administration of 99mTc-Sn colloid.

Methods

Three patients were treated with 32P-chromic phosphate colloid following 99mTc-Sn colloid administrations. Convolution dosimetry was performed using pretherapy and posttherapy sequential SPECT imaging, and verified with EGSnrc Monte Carlo radiation transport simulations. Mean absorbed doses to the cyst wall and dose–volume histograms were also calculated and compared with those obtained by the sphere model approach.

Results

Highly nonuniform uptake distributions of both the 99mTc and 32P colloids were observed and characterized by dose–volume histograms to the cyst wall. Mean absorbed doses delivered to the cyst wall, obtained with the convolution method, were on average 21 % (SD 18 %) and 50 % (SD 30 %) lower than those predicted by the 99mTc distribution and the uniform assumption of the sphere model, respectively.

Conclusion

Absorbed doses delivered to the cyst wall by 32P are more accurately predicted from image-based patient-specific convolution dosimetry than from simple sphere models. These results indicate the necessity to perform personalized treatment planning and verification for intracavitary irradiation of cystic brain tumours treated with radiocolloids. Patient-specific dosimetry can be used to guide the frequency and levels of repeated administrations and would facilitate data collection and comparison to support the multicentre trials necessary to progress this therapy.

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Acknowledgments

This work was supported by the CRUK/EPSRC Cancer Imaging Centre in association with MRC and the Department of Health C1060/A10334, NHS funding to the NIHR Biomedical Research Centre and the Clinical Research Facility in Imaging, and the Multimodality Techniques for Cancer Diagnosis and Therapy EPSRC platform grant EP/H046526/1.

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Authors and Affiliations

  1. Joint Department of Physics, Institute of Cancer Research, Sutton, London, SM2 5NG, UK

    Ana M. Denis-Bacelar & Marina Romanchikova

  2. Joint Department of Physics, Royal Marsden NHS Foundation Trust, Sutton, London, SM2 5PT, UK

    Sarah Chittenden & Glenn D. Flux

  3. Department of Pediatric Oncology, Royal Marsden NHS Foundation Trust, Sutton, London, SM2 5PT, UK

    Frank H. Saran & Henry Mandeville

  4. Deparment of Nuclear Medicine and PET/CT, Royal Marsden NHS Foundation Trust, Sutton, London, SM2 5PT, UK

    Yong Du

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  1. Ana M. Denis-Bacelar
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  2. Marina Romanchikova
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Correspondence to Ana M. Denis-Bacelar.

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Denis-Bacelar, A.M., Romanchikova, M., Chittenden, S. et al. Patient-specific dosimetry for intracavitary 32P-chromic phosphate colloid therapy of cystic brain tumours. Eur J Nucl Med Mol Imaging 40, 1532–1541 (2013). https://doi.org/10.1007/s00259-013-2451-6

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  • DOI: https://doi.org/10.1007/s00259-013-2451-6

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