Abstract
Purpose
The aim of the study was to evaluate the effect of phosphorus-32 colloid ([32P]) intracavitary irradiation on the treatment of patients with cystic craniopharyngiomas.
Methods
Twenty patients with predominantly cystic craniopharyngiomas were admitted from 1981 to 2006. Eleven patients had [32P] intracavitary irradiation by stereotactic injection or Ommaya cyst instillation as the primary treatment, and the remaining nine had the same internal irradiation as an adjuvant treatment after tumor resection. A calculated irradiation dose of 400~500 Gy per once was delivered to the cyst wall.
Conclusion
The patients were followed up ranging from 36 to 336 months; no operative morbidity or mortality was found from [32P] intracavitary irradiation. Fourteen patients (70%) had tumor progression and required further two to four times intracavitary irradiation. All 20 cases achieved tumor shrinkage or stabilization with effective outcome 3–6 months after the last [32P] therapy. For patients with cystic craniopharyngioma, [32P] administration by stereotactic injection or Ommaya cyst instillation is a safe and helpful option, which could improve the life quality, prolong the life span, and enhance the survival rate of cystic craniopharyngioma patients.
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Acknowledgments
The authors acknowledge the cooperation and assistance of Professor Weiping Liu and Professor Yi Wang, Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University.
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Rong Zhao and Jinglan Deng contributed equally to this work.
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Zhao, R., Deng, J., Liang, X. et al. Treatment of cystic craniopharyngioma with phosphorus-32 intracavitary irradiation. Childs Nerv Syst 26, 669–674 (2010). https://doi.org/10.1007/s00381-009-1025-1
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DOI: https://doi.org/10.1007/s00381-009-1025-1