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Regulatory, ethical, and technical considerations on regenerative technologies and adipose-derived mesenchymal stem cells

  • Master Class in Plastic Surgery
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Abstract

Since the early days of molecular biology, organ and tissue regeneration represents a challenging medical goal. However, only recently the advances in the understanding of the cellular components have enabled the promise to become a reality. In this vast panorama of new technologies, stem cells have progressively established themselves as the most effective and user-friendly regenerative therapeutic tool. Scientific meetings, workshops, conferences, and forums focused on translational science of regenerative technologies are today blooming all over the world. The audience questions and, even more, the very often controversial and conflicting explanations highlight the great deal of confusion regarding this new discipline that should be considered today a real independent medical specialty, requiring long-term studies and dedication. All the technologies able to separate and concentrate the adipose tissue (AT) and the stromal vascular fraction (SVF) and their related clinical applications need to comply with a complex but still unclear regulatory frame, becoming everyday more severe and restrictive, this limiting their practical use. The aim of this manuscript is to overview the current status of the regulatory frame and few related ethical considerations and to describe the evolution in the way the adipose-derived stromal vascular fraction (SVF) is isolated, extracted, and concentrated, as well as, of the ongoing researches and related future perspectives. Considerations on the most controversial and still unclear points related to the regenerative medicine and surgery, seen from the perspective of a research group who dedicated their entire professional life to this field, are also provided.

Level of evidence: Not ratable.

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Authors and Affiliations

  1. C.S.M. Institute for Regenerative Surgery, Turin, Italy

    Michele L. Zocchi

  2. Institute of Plastic and Reconstructive Surgery of the University of Padua, Padua, Italy

    Michele L. Zocchi, Vincenzo Vindigni, Andrea Pagani, Ortensia Pirro & Franco Bassetto

  3. Institute of Human Anatomy, University of Verona, Verona, Italy

    Giamaica Conti & Andrea Sbarbati

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  1. Michele L. Zocchi
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  2. Vincenzo Vindigni
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  3. Andrea Pagani
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  4. Ortensia Pirro
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  5. Giamaica Conti
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Correspondence to Michele L. Zocchi.

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Michele L. Zocchi, Vincenzo Vindigni, Andrea Pagani, Ortensia Pirr, Giamaica Contio, Andrea Sbarbati, and Franco Bassetto declare that they have no conflict of interest.

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No need of any ethical approval because the topic of the article is mainly related to basic science behind regenerative surgery and no direct action on patients has been taken and referred in the article.

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Zocchi, M.L., Vindigni, V., Pagani, A. et al. Regulatory, ethical, and technical considerations on regenerative technologies and adipose-derived mesenchymal stem cells. Eur J Plast Surg 42, 531–548 (2019). https://doi.org/10.1007/s00238-019-01571-5

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