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Development of urine standard reference materials for metabolites of organic chemicals including polycyclic aromatic hydrocarbons, phthalates, phenols, parabens, and volatile organic compounds

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Abstract

Two new Standard Reference Materials (SRMs), SRM 3672 Organic Contaminants in Smokers’ Urine (Frozen) and SRM 3673 Organic Contaminants in Non-Smokers’ Urine (Frozen), have been developed in support of studies for assessment of human exposure to select organic environmental contaminants. Collaborations among three organizations resulted in certified values for 11 hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and reference values for 11 phthalate metabolites, 8 environmental phenols and parabens, and 24 volatile organic compound (VOC) metabolites. Reference values are also available for creatinine and the free forms of caffeine, theobromine, ibuprofen, nicotine, cotinine, and 3-hydroxycotinine. These are the first urine Certified Reference Materials characterized for metabolites of organic environmental contaminants. Noteworthy, the mass fractions of the environmental organic contaminants in the two SRMs are within the ranges reported in population survey studies such as the National Health and Nutrition Examination Survey (NHANES) and the Canadian Health Measures Survey (CHMS). These SRMs will be useful as quality control samples for ensuring compatibility of results among population survey studies and will fill a void to assess the accuracy of analytical methods used in studies monitoring human exposure to these organic environmental contaminants.

Metabolites of PAHs, Phthalates, Phenols, Parabens, and VOCs in Urine SRMs

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Disclaimer

Certain commercial equipment, instruments, or materials are identified in this paper to specify adequately the experimental procedure. Such identification does not imply recommendation or endorsement by the National Institute of Standards and Technology, nor does it imply that the materials or equipment identified are necessarily the best available for the purpose. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

Author information

Authors and Affiliations

  1. Chemical Sciences Division, National Institute of Standards and Technology, Gaithersburg, MD, 20899, USA

    Michele M. Schantz, Bruce A. Benner Jr., Lane C. Sander, Katherine E. Sharpless, Stacy S. Vander Pol, Y. Vasquez, M. Villegas & Stephen A. Wise

  2. Statistical Engineering Division, National Institute of Standards and Technology, Charleston, SC, 29412, USA

    N. Alan Heckert

  3. National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA

    K. Udeni Alwis, Benjamin C. Blount, Antonia M. Calafat, Zheng Li, Manori J. Silva, Xiaoyun Ye & Andreas Sjödin

  4. Toxicology Laboratory, Institut National de Santé Publique du Québec, 945, Avenue Wolfe, Québec, Québec, G1V 5B3, Canada

    Éric Gaudreau

  5. Environ Solutions Consulting, Inc., 4921 Bull Creek Road, Auburn, GA, 30011, USA

    Donald G. Patterson Jr

  6. Centro de Metrologia Quimica, Fundación Chile, 8320000, Santiago, Chile

    Y. Vasquez & M. Villegas

Authors
  1. Michele M. Schantz
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  2. Bruce A. Benner Jr.
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  3. N. Alan Heckert
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  4. Lane C. Sander
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  5. Katherine E. Sharpless
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  6. Stacy S. Vander Pol
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  7. Y. Vasquez
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  8. M. Villegas
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  9. Stephen A. Wise
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  10. K. Udeni Alwis
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  11. Benjamin C. Blount
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  12. Antonia M. Calafat
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  13. Zheng Li
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  14. Manori J. Silva
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  15. Xiaoyun Ye
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  16. Éric Gaudreau
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  17. Donald G. Patterson Jr
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  18. Andreas Sjödin
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Corresponding author

Correspondence to Michele M. Schantz.

Additional information

Published in the topical collection Reference Materials for Chemical Analysis with guest editors Hendrik Emons and Stephen A. Wise.

Contribution of the US Government; not subject to copyright

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Schantz, M.M., Benner, B.A., Heckert, N.A. et al. Development of urine standard reference materials for metabolites of organic chemicals including polycyclic aromatic hydrocarbons, phthalates, phenols, parabens, and volatile organic compounds. Anal Bioanal Chem 407, 2945–2954 (2015). https://doi.org/10.1007/s00216-014-8441-0

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  • DOI: https://doi.org/10.1007/s00216-014-8441-0

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