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Vitamin D and chronic diseases: the current state of the art

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Abstract

The objective was to provide the current state of the art regarding the role of vitamin D in chronic diseases (osteoporosis, cancer, cardiovascular diseases, dementia, autism, type 1 and type 2 diabetes mellitus, male and female fertility). The document was drawn up by panelists that provided their contribution according to their own scientific expertise. Each scientific expert supplied a first draft manuscript on a specific aspect of the document’s topic that was subjected to voting by all experts as “yes” (agreement with the content and/or wording) or “no” (disagreement). The adopted rule was that statements supported by ≥75 % of votes would be immediately accepted, while those with <25 % would be rejected outright. Others would be subjected to further discussion and subsequent voting, where ≥67 % support or, in an eventual third round, a majority of ≥50 % would be needed. This document finds that the current evidence support a role for vitamin D in bone health but not in other health conditions. However, subjects with vitamin D deficiency have been found to be at high risk of developing chronic diseases. Therefore, although at the present time there is not sufficient evidence to recommend vitamin D supplementation as treatment of chronic diseases, the treatment of vitamin D deficiency should be desiderable in order to reduce the risk of developing chronic diseases.

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References

  • Annweiler C, Beauchet O (2013) Vitamin D and cognition: recommendations for future trials. J Am Geriatr Soc 61(6):1049–1050

    Article  PubMed  Google Scholar 

  • Annweiler C, Beauchet O (2014) Vitamin d in older adults: the need to specify standard values with respect to cognition. Front Aging Neurosci 6:72

    Article  PubMed  PubMed Central  Google Scholar 

  • Annweiler C, Dursun E, Feron F, Gezen-Ak D, Kalueff AV, Littlejohns T, Llewellyn DJ, Millet P, Scott T, Tucker KL, Yilmazer S, Beauchet O (2015) ‘Vitamin D and cognition in older adults’: updated international recommendations. J Intern Med 277(1):45–57

    Article  CAS  PubMed  Google Scholar 

  • Avenell A, Gillespie WJ, Gillespie LD, O’Connell D (2009) Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database Syst Rev (2):CD000227. doi:10.1002/14651858.CD000227.pub3

  • Bellastella G, Maiorino MI, Olita L, Capuano A, Rafaniello C, Giugliano D, Esposito K (2014) Vitamin D deficiency in type 2 diabetic patients with hypogonadism. J Sex Med 11(2):536–542

    Article  CAS  PubMed  Google Scholar 

  • Bierschenk L, Alexander J, Wasserfall C, Haller M, Schatz D, Atkinson M (2009) Vitamin D levels in subjects with and without type 1 diabetes residing in a solar rich environment. Diabetes Care 32(11):1977–1979

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bischoff-Ferrari HA (2012) Which vitamin D oral supplement is best for postmenopausal women? Curr Osteoporos Rep 10(4):251–257

    Article  PubMed  Google Scholar 

  • Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B (2005) Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 293(18):2257–2264

    Article  CAS  PubMed  Google Scholar 

  • Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA, Flicker L, Wark J, Jackson RD, Cauley JA, Meyer HE, Pfeifer M, Sanders KM, Stahelin HB, Theiler R, Dawson-Hughes B (2012) A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 367(1):40–49

    Article  CAS  PubMed  Google Scholar 

  • Blomberg Jensen M (2012) Vitamin D metabolism, sex hormones, and male reproductive function. Reproduction 144(2):135–152

    Article  PubMed  Google Scholar 

  • Blomberg Jensen M, Bjerrum PJ, Jessen TE, Nielsen JE, Joensen UN, Olesen IA, Petersen JH, Juul A, Dissing S, Jorgensen N (2011) Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Hum Reprod 26(6):1307–1317

    Article  CAS  PubMed  Google Scholar 

  • Blomberg Jensen M, Jorgensen A, Nielsen JE, Bjerrum PJ, Skalkam M, Petersen JH, Egeberg DL, Bangsboll S, Andersen AN, Skakkebaek NE, Juul A, Rajpert-De Meyts E, Dissing S, Leffers H, Jorgensen N (2012) Expression of the vitamin D metabolizing enzyme CYP24A1 at the annulus of human spermatozoa may serve as a novel marker of semen quality. Int J Androl 35(4):499–510

    Article  CAS  PubMed  Google Scholar 

  • Bolland MJ, Grey A, Gamble GD, Reid IR (2011) Calcium and vitamin D supplements and health outcomes: a reanalysis of the Women’s Health Initiative (WHI) limited-access data set. Am J Clin Nutr 94(4):1144–1149

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Boonen S, Lips P, Bouillon R, Bischoff-Ferrari HA, Vanderschueren D, Haentjens P (2007) Need for additional calcium to reduce the risk of hip fracture with vitamin d supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab 92(4):1415–1423

    Article  CAS  PubMed  Google Scholar 

  • Boucher BJ (1998) Inadequate vitamin D status: Does it contribute to the disorders comprising syndrome ‘X’? Br J Nutr 79(4):315–327

    Article  CAS  PubMed  Google Scholar 

  • Cashman KD (2015) Vitamin D: dietary requirements and food fortification as a means of helping achieve adequate vitamin D status. J Steroid Biochem Mol Biol 148:19–26

    Article  CAS  PubMed  Google Scholar 

  • Cheng Q, Boucher BJ, Leung PS (2013) Modulation of hypovitaminosis D-induced islet dysfunction and insulin resistance through direct suppression of the pancreatic islet renin-angiotensin system in mice. Diabetologia 56(3):553–562

    Article  CAS  PubMed  Google Scholar 

  • Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S, Lindsay R, National Osteoporosis F (2014) Clinician’s guide to prevention and treatment of osteoporosis. Osteoporos Int 25(10):2359–2381

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Esteghamati A, Fotouhi A, Faghihi-Kashani S, Hafezi-Nejad N, Heidari B, Sheikhbahaei S, Zandieh A, Nakhjavani M (2016) Non-linear contribution of serum vitamin D to symptomatic diabetic neuropathy: a case–control study. Diabetes Res Clin Pract 111:44–50

    Article  CAS  PubMed  Google Scholar 

  • Feng J, Shan L, Du L, Wang B, Li H, Wang W, Wang T, Dong H, Yue X, Xu Z, Staal WG, Jia F (2016) Clinical improvement following vitamin D3 supplementation in autism spectrum disorder. Nutr Neurosci. doi:10.1080/1028415X.2015.1123847

  • Fleet JC, DeSmet M, Johnson R, Li Y (2012) Vitamin D and cancer: a review of molecular mechanisms. Biochem J 441(1):61–76

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ford JA, MacLennan GS, Avenell A, Bolland M, Grey A, Witham M, Group RT (2014) Cardiovascular diseases and vitamin D supplementation: trial analysis, systematic review, and meta-analysis. Am J Clin Nutr 100(3):746–755

    Article  CAS  PubMed  Google Scholar 

  • Grant WB (2015) 25-hydroxyvitamin D and breast cancer, colorectal cancer, and colorectal adenomas: case–control versus nested case–control studies. Anticancer Res 35(2):1153–1160

    CAS  PubMed  Google Scholar 

  • Grant WB (2016) Roles of solar UVB and vitamin D in reducing cancer risk and increasing survival. Anticancer Res 36(3):1357–1370

    CAS  PubMed  Google Scholar 

  • Grimnes G, Joakimsen R, Figenschau Y, Torjesen PA, Almas B, Jorde R (2012) The effect of high-dose vitamin D on bone mineral density and bone turnover markers in postmenopausal women with low bone mass—a randomized controlled 1-year trial. Osteoporos Int 23(1):201–211

    Article  CAS  PubMed  Google Scholar 

  • Group D (2010) Patient level pooled analysis of 68,500 patients from seven major vitamin D fracture trials in US and Europe. BMJ 340:b5463

    Article  Google Scholar 

  • Hammoud AO, Meikle AW, Peterson CM, Stanford J, Gibson M, Carrell DT (2012) Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters. Asian J Androl 14(6):855–859

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • He C, Lin Z, Robb SW, Ezeamama AE (2015) Serum vitamin D levels and polycystic ovary syndrome: a systematic review and meta-analysis. Nutrients 7(6):4555–4577

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Heijboer AC, Oosterwerff M, Schroten NF, Eekhoff EM, Chel VG, de Boer RA, Blankenstein MA, Lips P (2015) Vitamin D supplementation and testosterone concentrations in male human subjects. Clin Endocrinol 83(1):105–110

    Article  CAS  Google Scholar 

  • Hirschler V, Maccallini G, Sanchez M, Claudio G, Molinari C, San Antonio de los Cobres Study Group Collaborators Graciela C, Figueroa M, Arnada C, Hidalgo M (2015) Improvement of apolipoprotein B in argentine indigenous school children after vitamin D supplementation. Cardiovasc Hematol Agents Med Chem 13(2):137–145

  • Hirschler V, Maccallini G, Tamborenea MI, Gonzalez C, Sanchez M, Molinari C, San Antonio de Los Cobres Study G, Castano L, Colque G, Hidalgo M, Urzagasti M (2014) Improvement in lipid profile after vitamin D supplementation in indigenous argentine school children. Cardiovasc Hematol Agents Med Chem 12(1):42–49

  • Holick MF (2007) Vitamin D deficiency. N Engl J Med 357(3):266–281

    Article  CAS  PubMed  Google Scholar 

  • Holick MF, Chen TC (2008) Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 87(4):1080S–1086S

    CAS  PubMed  Google Scholar 

  • Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM, Endocrine S (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96(7):1911–1930

    Article  CAS  PubMed  Google Scholar 

  • Huang Y, Jin H, Chen J, Jiang X, Li P, Ren Y, Liu W, Yao J, Folger JK, Smith GW, Lv L (2015) Effect of Vitamin D on basal and Luteinizing Hormone (LH) induced testosterone production and mitochondrial dehydrogenase activity in cultured Leydig cells from immature and mature rams. Anim Reprod Sci 158:109–114

    Article  CAS  PubMed  Google Scholar 

  • Jorde R, Grimnes G, Hutchinson MS, Kjaergaard M, Kamycheva E, Svartberg J (2013) Supplementation with vitamin D does not increase serum testosterone levels in healthy males. Horm Metab Res 45(9):675–681

    Article  CAS  PubMed  Google Scholar 

  • Kalueff AV, Tuohimaa P (2007) Neurosteroid hormone vitamin D and its utility in clinical nutrition. Curr Opin Clin Nutr Metab Care 10(1):12–19

    Article  CAS  PubMed  Google Scholar 

  • Kelishadi R, Farajzadegan Z, Bahreynian M (2014) Association between vitamin D status and lipid profile in children and adolescents: a systematic review and meta-analysis. Int J Food Sci Nutr 65(4):404–410

    Article  CAS  PubMed  Google Scholar 

  • Kwiecinski GG, Petrie GI, DeLuca HF (1989) Vitamin D is necessary for reproductive functions of the male rat. J Nutr 119(5):741–744

    CAS  PubMed  Google Scholar 

  • Lamichhane AP, Crandell JL, Jaacks LM, Couch SC, Lawrence JM, Mayer-Davis EJ (2015) Longitudinal associations of nutritional factors with glycated hemoglobin in youth with type 1 diabetes: the SEARCH Nutrition Ancillary Study. Am J Clin Nutr 101(6):1278–1285

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP (2007) Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr 85(6):1586–1591

    CAS  PubMed  Google Scholar 

  • Lee DM, Tajar A, Pye SR, Boonen S, Vanderschueren D, Bouillon R, O’Neill TW, Bartfai G, Casanueva FF, Finn JD, Forti G, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean ME, Pendleton N, Punab M, Wu FC, Group Es (2012) Association of hypogonadism with vitamin D status: the European Male Ageing Study. Eur J Endocrinol/Eur Fed Endocr Soc 166(1):77–85

    Article  CAS  Google Scholar 

  • Lerchbaum E, Obermayer-Pietsch B (2012) Vitamin D and fertility: a systematic review. Eur J Endocrinol/Eur Fed Endocr Soc 166(5):765–778

    Article  CAS  Google Scholar 

  • Lerchbaum E, Pilz S, Trummer C, Rabe T, Schenk M, Heijboer AC, Obermayer-Pietsch B (2014) Serum vitamin D levels and hypogonadism in men. Andrology 2(5):748–754

    Article  CAS  PubMed  Google Scholar 

  • Leung PS (2016) The potential protective action of vitamin D in hepatic insulin resistance and pancreatic islet dysfunction in type 2 Diabetes mellitus. Nutrients 8(3):147

  • Levis S, Theodore G (2012) Summary of AHRQ’s comparative effectiveness review of treatment to prevent fractures in men and women with low bone density or osteoporosis: update of the 2007 report. J Manag Care Pharm 18(4 Suppl B):S1–S15 (discussion S13)

    PubMed  Google Scholar 

  • Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP (2002) 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Investig 110(2):229–238

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D (2010) Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med 170(13):1135–1141

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Macdonald HM, Wood AD, Aucott LS, Black AJ, Fraser WD, Mavroeidi A, Reid DM, Secombes KR, Simpson WG, Thies F (2013) Hip bone loss is attenuated with 1000 IU but not 400 IU daily vitamin D3: a 1-year double-blind RCT in postmenopausal women. J Bone Miner Res 28(10):2202–2213

    Article  CAS  PubMed  Google Scholar 

  • Mathieu C (2015) Vitamin D and diabetes: Where do we stand? Diabetes Res Clin Pract 108(2):201–209

    Article  CAS  PubMed  Google Scholar 

  • Meguid NA, Hashish AF, Anwar M, Sidhom G (2010) Reduced serum levels of 25-hydroxy and 1,25-dihydroxy vitamin D in Egyptian children with autism. J Altern Complement Med 16(6):641–645

    Article  PubMed  Google Scholar 

  • Moukayed M, Grant WB (2013) Molecular link between vitamin D and cancer prevention. Nutrients 5(10):3993–4021

    Article  PubMed  PubMed Central  Google Scholar 

  • Muscogiuri G, Mitri J, Mathieu C, Badenhoop K, Tamer G, Orio F, Mezza T, Vieth R, Colao A, Pittas A (2014) Mechanisms in endocrinology: vitamin D as a potential contributor in endocrine health and diseases. Eur J Endocrinol/Eur Fed Endocr Soc 171(3):R101–R110

    Article  CAS  Google Scholar 

  • Norman PE, Powell JT (2014) Vitamin D and cardiovascular diseases. Circ Res 114(2):379–393

    Article  CAS  PubMed  Google Scholar 

  • Ooms ME, Roos JC, Bezemer PD, van der Vijgh WJ, Bouter LM, Lips P (1995) Prevention of bone loss by vitamin D supplementation in elderly women: a randomized double-blind trial. J Clin Endocrinol Metab 80(4):1052–1058

    CAS  PubMed  Google Scholar 

  • Parikh G, Varadinova M, Suwandhi P, Araki T, Rosenwaks Z, Poretsky L, Seto-Young D (2010) Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells. Horm Metab Res 42(10):754–757

    Article  CAS  PubMed  Google Scholar 

  • Pilz S, Frisch S, Koertke H, Kuhn J, Dreier J, Obermayer-Pietsch B, Wehr E, Zittermann A (2011) Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res 43(3):223–225

    Article  CAS  PubMed  Google Scholar 

  • Pilz S, Rutters F, Dekker JM (2012) Diseases prevention: vitamin D trials. Science 338(6109):883

    Article  CAS  PubMed  Google Scholar 

  • Pilz S, Gaksch M, O’Hartaigh B, Tomaschitz A, Marz W (2013) The role of vitamin D deficiency in cardiovascular diseases: Where do we stand in 2013? Arch Toxicol 87(12):2083–2103

    Article  CAS  PubMed  Google Scholar 

  • Pittas AG, Lau J, Hu FB, Dawson-Hughes B (2007) The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 92(6):2017–2029

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ramlau-Hansen CH, Moeller UK, Bonde JP, Olsen J, Thulstrup AM (2011) Are serum levels of vitamin D associated with semen quality? Results from a cross-sectional study in young healthy men. Fertil Steril 95(3):1000–1004

    Article  CAS  PubMed  Google Scholar 

  • Rojansky N, Brzezinski A, Schenker JG (1992) Seasonality in human reproduction: an update. Hum Reprod 7(6):735–745

    CAS  PubMed  Google Scholar 

  • Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA (2011) The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 96(1):53–58

    Article  CAS  PubMed  Google Scholar 

  • Saad K, Abdel-Rahman AA, Elserogy YM, Al-Atram AA, Cannell JJ, Bjorklund G, Abdel-Reheim MK, Othman HA, El-Houfey AA, Abd El-Aziz NH, Abd El-Baseer KA, Ahmed AE, Ali AM (2015) Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children. Nutr Neurosci. doi:10.1179/1476830515Y.0000000019

    PubMed  Google Scholar 

  • Scholten SD, Sergeev IN, Song Q, Birger CB (2015) Effects of vitamin D and quercetin, alone and in combination, on cardiorespiratory fitness and muscle function in physically active male adults. Open Access J Sports Med 6:229–239

    Article  PubMed  PubMed Central  Google Scholar 

  • Shab-Bidar S, Neyestani TR, Djazayery A (2015) Vitamin D receptor Cdx-2-dependent response of central obesity to vitamin D intake in the subjects with type 2 diabetes: a randomised clinical trial. Br J Nutr 114(9):1375–1384

    Article  CAS  PubMed  Google Scholar 

  • Sonnenberg J, Luine VN, Krey LC, Christakos S (1986) 1,25-Dihydroxyvitamin D3 treatment results in increased choline acetyltransferase activity in specific brain nuclei. Endocrinology 118(4):1433–1439

    Article  CAS  PubMed  Google Scholar 

  • Stubbs G, Henley K, Green J (2016) Autism: Will vitamin D supplementation during pregnancy and early childhood reduce the recurrence rate of autism in newborn siblings? Med Hypotheses 88:74–78

    Article  CAS  PubMed  Google Scholar 

  • Tak YJ, Lee JG, Kim YJ, Park NC, Kim SS, Lee S, Cho BM, Kong EH, Jung DW, Yi YH (2015) Serum 25-hydroxyvitamin D levels and testosterone deficiency in middle-aged Korean men: a cross-sectional study. Asian J Androl 17(2):324–328

    Article  CAS  PubMed  Google Scholar 

  • Tartagni M, Matteo M, Baldini D, Tartagni MV, Alrasheed H, De Salvia MA, Loverro G, Montagnani M (2015) Males with low serum levels of vitamin D have lower pregnancy rates when ovulation induction and timed intercourse are used as a treatment for infertile couples: results from a pilot study. Reprod Biol Endocrinol 13:127

    Article  PubMed  PubMed Central  Google Scholar 

  • Tepper S, Shahar DR, Geva D, Ish-Shalom S (2016) Differences in homeostatic model assessment (HOMA) values and insulin levels after vitamin D supplementation in healthy men: a double-blind randomized controlled trial. Diabetes Obes Metab 18(6):633–637

    Article  CAS  PubMed  Google Scholar 

  • Thomson RL, Spedding S, Buckley JD (2012) Vitamin D in the aetiology and management of polycystic ovary syndrome. Clin Endocrinol 77(3):343–350

    Article  CAS  Google Scholar 

  • Van Belle TL, Gysemans C, Mathieu C (2013) Vitamin D and diabetes: the odd couple. Trends Endocrinol Metab 24(11):561–568

    Article  PubMed  Google Scholar 

  • Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, Kiel DP, Streeten EA, Ohlsson C, Koller DL, Peltonen L, Cooper JD, O’Reilly PF, Houston DK, Glazer NL, Vandenput L, Peacock M, Shi J, Rivadeneira F, McCarthy MI, Anneli P, de Boer IH, Mangino M, Kato B, Smyth DJ, Booth SL, Jacques PF, Burke GL, Goodarzi M, Cheung CL, Wolf M, Rice K, Goltzman D, Hidiroglou N, Ladouceur M, Wareham NJ, Hocking LJ, Hart D, Arden NK, Cooper C, Malik S, Fraser WD, Hartikainen AL, Zhai G, Macdonald HM, Forouhi NG, Loos RJ, Reid DM, Hakim A, Dennison E, Liu Y, Power C, Stevens HE, Jaana L, Vasan RS, Soranzo N, Bojunga J, Psaty BM, Lorentzon M, Foroud T, Harris TB, Hofman A, Jansson JO, Cauley JA, Uitterlinden AG, Gibson Q, Jarvelin MR, Karasik D, Siscovick DS, Econs MJ, Kritchevsky SB, Florez JC, Todd JA, Dupuis J, Hypponen E, Spector TD (2010) Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376(9736):180–188

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang N, Han B, Li Q, Chen Y, Chen Y, Xia F, Lin D, Jensen MD, Lu Y (2015) Vitamin D is associated with testosterone and hypogonadism in Chinese men: results from a cross-sectional SPECT-China study. Reprod Biol Endocrinol 13:74

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang B, Sun H, Wan Y, Wang H, Qin W, Yang L, Zhao H, Yuan J, Yao B (2012) Associations between testosterone, bone mineral density, vitamin D and semen quality in fertile and infertile Chinese men. Int J Androl 35(6):783–792

    Article  CAS  PubMed  Google Scholar 

  • Yilmaz O, Olgun H, Ciftel M, Kilic O, Kartal I, Iskenderoglu NY, Laloglu F, Ceviz N (2015) Dilated cardiomyopathy secondary to rickets-related hypocalcaemia: eight case reports and a review of the literature. Cardiol Young 25(2):261–266

    Article  PubMed  Google Scholar 

  • Zhu CL, Xu QF, Li SX, Wei YC, Zhu GC, Yang C, Shi YC (2016) Investigation of serum vitamin D levels in Chinese infertile men. Andrologia. doi:10.1111/and.12570

  • Zipitis CS, Akobeng AK (2008) Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch Dis Child 93(6):512–517

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Ios and Coleman Medicina Futura Medical Center, University “Federico II”, Naples, Italy

    Giovanna Muscogiuri

  2. Department of Endocrinology and Metabolic Diseases, Catholic University of the Sacred Heart, Rome, Italy

    Barbara Altieri

  3. Division of Geriatric Medicine, Department of Neuroscience, Angers University Hospital, University Memory Clinic, UPRES EA 4638, University of Angers, UNAM, Angers, France

    Cedric Annweiler

  4. Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Robarts Research Institute, The University of Western Ontario, London, ON, Canada

    Cedric Annweiler

  5. Division of Endocrinology, Department of Clinical and Molecular Sciences, Umberto I Hospital, Polytechnic University of Marche, Ancona, Italy

    Giancarlo Balercia & Giacomo Tirabassi

  6. Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

    H. B. Pal

  7. The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

    Barbara J. Boucher

  8. Vitamin D Council, San Luis Obispo, CA, USA

    John J. Cannell

  9. Department of Medicine, Operative Unit of Andrology and Medicine of Human Reproduction, University of Padova, Padua, Italy

    Carlo Foresta

  10. Department of Cardiology, Swiss Cardiovascular Center Bern, Bern University Hospital, Bern, Switzerland

    Martin R. Grübler

  11. Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria

    Martin R. Grübler & Stefan Pilz

  12. Division of Endocrinology and Metabolism, Department of Medicine, AHEPA University Hospital, Thessaloníki, Greece

    Kalliopi Kotsa

  13. Comando Brigata Alpina “Julia”/Multinational Land Force, Medical Service, Udine, Italy

    Luca Mascitelli

  14. Medical Clinic V (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany

    Winfried März

  15. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria

    Winfried März

  16. Synlab Academy, Synlab Holding Germany GmbH, Mannheim, Augsburg, Germany

    Winfried März

  17. Department of Endocrinology and Diabetology, Fertility Techniques Structure, University Hospital “S. Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy

    Francesco Orio

  18. Department of Sports Science and Wellness, “Parthenope” University Naples, Naples, Italy

    Francesco Orio

  19. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands

    Stefan Pilz

  20. Department of Clinical Medicine and Surgery, University “Federico II”, Naples, Italy

    Annamaria Colao

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  1. Giovanna Muscogiuri
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  2. Barbara Altieri
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  8. Carlo Foresta
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  9. Martin R. Grübler
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  11. Luca Mascitelli
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  13. Francesco Orio
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  14. Stefan Pilz
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  15. Giacomo Tirabassi
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  16. Annamaria Colao
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Correspondence to Giovanna Muscogiuri.

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Muscogiuri, G., Altieri, B., Annweiler, C. et al. Vitamin D and chronic diseases: the current state of the art. Arch Toxicol 91, 97–107 (2017). https://doi.org/10.1007/s00204-016-1804-x

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  • DOI: https://doi.org/10.1007/s00204-016-1804-x

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