Abstract
Introduction and hypothesis
The objective was to analyse the risk of significant bacteriuria in repeat urine cultures from pregnant women, following initial mixed bacterial results.
Methods
This retrospective study examined maternal characteristics and clinical features of women who repeated urine cultures due to previous mixed cultures results.
Results
Of 262 women included, 80 (30.5%) had negative cultures and 125 (47.7%) had mixed bacterial growth in their repeat cultures. Positive results (≥104 CFU/ml of a urinary pathogen) were obtained for 57 women (21.8% [95% CI 17.1–27.0]). For 37 (14.1%), the repeat specimen grew 104–105 CFU/ml of microorganisms; whereas for 20 women (7.6% [95% CI 4.9–11.3]), it grew ≥105 CFU/ml. Among women with positive (>104 CFU/ml) compared with those with negative or mixed growth, rates of urinary symptoms were higher (38.6% vs 23.4%, p=0.028), abnormal dipstick results (49.1% vs 21.0%, p<0.001) and hydronephrosis, as demonstrated by renal ultrasound (12.3% vs 2.0, p=0.003). In a multivariate logistic regression analysis, hydronephrosis was associated with the occurrence of a positive repeat culture (aOR = 10.65, 95% CI 2.07–54.90). The sensitivity and specificity for predicting a repeat urine culture with ≥105 CFU/ml were 12.9% and 94.3% respectively, for urinary symptoms; and 19.7% and 97.4% respectively, for abnormal dipstick results.
Conclusions
Mixed bacterial growth might represent a true urinary tract infection in a considerable proportion of women who are symptomatic and have an abnormal dipstick urinalysis.
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Data availability
Data are available from the corresponding author upon reasonable request.
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Inshirah Sgayer: project developmet, data analysis, manuscript writing; Gabriel Shamalov: data collection; Silas Assi: data collection; Daniel Glikman: infectious diseases consultation, manuscript editing; Lior Lowenstein: manuscript editing; Maya Frank Wolf: protocol/project development, manuscript editing.
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Sgayer, I., Shamalov, G., Assi, S. et al. Bacteriology and clinical outcomes of urine mixed bacterial growth in pregnancy. Int Urogynecol J 35, 347–353 (2024). https://doi.org/10.1007/s00192-023-05672-5
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DOI: https://doi.org/10.1007/s00192-023-05672-5