References
Verga Falcacappa HV, Casanovas G, Heutze MW, Muckenthaler, MU (2008) A bone Morphogenetic protein (BMP) responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells. J Mol Med DOI 10.1007/s00109-008-0313-7
Wang RH, Li C, Xu X, Zheng Y, Xiao C, Zerfas P et al (2005) A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2(6):399–409 Dec
Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T (2007) Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood 110(6):2182–2189 Sep 15
Yu PB, Hong CC, Sachidanandan C, Babitt JL, Deng DY, Hoyng SA et al (2008) Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol 4(1):33–41 Jan
Truksa J, Lee P, Peng H, Flanagan J, Beutler E (2007) The distal location of the iron responsive region of the hepcidin promoter. Blood 110(9):3436–3437 Nov 1
Niederkofler V, Salie R, Arber S (2005) Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest 115(8):2180–2186 Aug
Roy CN, Custodio AO, de Graaf J, Schneider S, Akpan I, Montross LK et al (2004) An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Nat Genet 36(5):481–485 May
Lee P, Peng H, Gelbart T, Beutler E (2004) The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes. Proc Natl Acad Sci U S A 101(25):9263–9265 Jun 22
Frazer DM, Wilkins SJ, Millard KN, McKie AT, Vulpe CD, Anderson GJ (2004) Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE. Br J Haematol 126(3):434–436 Aug
Constante M, Jiang W, Wang D, Raymond VA, Bilodeau M, Santos MM (2006) Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation. Am J Physiol Gastrointest Liver Physiol 291(2):G229–G237 Aug
Chlosta S, Fishman DS, Harrington L, Johnson EE, Knutson MD, Wessling-Resnick M et al (2006) The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica. Infect Immun 74(5):3065–3067 May
Moalem S, Weinberg ED, Percy ME (2004) Hemochromatosis and the enigma of misplaced iron: implications for infectious disease and survival. Biometals 17(2):135–139 Apr
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Fleming, R.E. Iron and inflammation: cross-talk between pathways regulating hepcidin. J Mol Med 86, 491–494 (2008). https://doi.org/10.1007/s00109-008-0349-8
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00109-008-0349-8