Abstract
Cells are dynamic structures that continually generate and sustain mechanical forces within their environments. Cells respond to mechanical forces by changing their shape, moving, and differentiating. These reactions are caused by intracellular skeletal changes, which induce changes in cellular mechanical properties such as stiffness, elasticity, viscoelasticity, and adhesiveness. Interdisciplinary research combining molecular biology with physics and mechanical engineering has been conducted to characterize cellular mechanical properties and understand the fundamental mechanisms of mechanotransduction. In this review, we focus on the role of cytoskeletal proteins in cellular mechanics. The specific role of each cytoskeletal protein, including actin, intermediate filaments, and microtubules, on cellular elasticity is summarized along with the effects of interactions between the fibers.
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This research was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (Grant No. NRF-2017R1A2B2010145).
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Sangwoo Kwon and Kyung Sook Kim conceived this article and wrote the manuscript.
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Kwon, S., Kim, K.S. Qualitative analysis of contribution of intracellular skeletal changes to cellular elasticity. Cell. Mol. Life Sci. 77, 1345–1355 (2020). https://doi.org/10.1007/s00018-019-03328-6
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DOI: https://doi.org/10.1007/s00018-019-03328-6