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Acute lung injury: a view from the perspective of necroptosis

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Abstract

Background

ALI/ARDS is a syndrome of acute onset characterized by progressive hypoxemia and noncardiogenic pulmonary edema as the primary clinical manifestations. Necroptosis is a form of programmed cell necrosis that is precisely regulated by molecular signals. This process is characterized by organelle swelling and membrane rupture, is highly immunogenic, involves extensive crosstalk with various cellular stress mechanisms, and is significantly implicated in the onset and progression of ALI/ARDS.

Methods

The current body of literature on necroptosis and ALI/ARDS was thoroughly reviewed. Initially, an overview of the molecular mechanism of necroptosis was provided, followed by an examination of its interactions with apoptosis, pyroptosis, autophagy, ferroptosis, PANOptosis, and NETosis. Subsequently, the involvement of necroptosis in various stages of ALI/ARDS progression was delineated. Lastly, drugs targeting necroptosis, biomarkers, and current obstacles were presented.

Conclusion

Necroptosis plays an important role in the progression of ALI/ARDS. However, since ALI/ARDS is a clinical syndrome caused by a variety of mechanisms, we emphasize that while focusing on necroptosis, it may be more beneficial to treat ALI/ARDS by collaborating with other mechanisms.

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Data availability

Data sharing does not apply to this article as no new data were created or analyzed in this study.

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Funding

This research was funded by Rui E Emergency Medicine Research Special Fund (No. 22222012021), National Natural Science Foundation (No. 82374234, No.82204876, No.81974545), China Postdoctoral Science Found (item2020M670045ZX), Postdoctoral Innovation Project of Shandong Province (item202003026), Taishan Scholar(NO.tsqn202103183), National Multidisciplinary Innovation Team Project of Traditional Chinese Medicine (No. ZYYCXTD-D-202201), Shandong Traditional Chinese Medicine Science and Technology Project (Z-2023036) and Shandong Province Medical and Health Technology Development Plan Project (No. 202210000429).

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Authors and Affiliations

  1. First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250000, Shandong, China

    Jinyan Dong, Wenli Liu, Qingkuo Liu, Hongtao Wang & Guohan Xiang

  2. Second Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250000, Shandong, China

    Yuqi Wen

  3. Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250000, Shandong, China

    Weihong Liu, Yang Liu & Hao Hao

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  1. Jinyan Dong
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  3. Wenli Liu
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Contributions

The conceptualization of the study was carried out by J.D. and W.L. The investigation was conducted by W.L. and Y.W. The initial draft of the manuscript was written by J.D. The review and editing of the manuscript were performed by H.H. and Y.L. The visualization of the data was done by Q.L., H.W., and G.X. The supervision of the study was provided by H.H. and Y.L. The funding for the study was acquired by H.H. All authors have reviewed and approved the final version of the manuscript for publication.

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Correspondence to Yang Liu or Hao Hao.

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Dong, J., Liu, W., Liu, W. et al. Acute lung injury: a view from the perspective of necroptosis. Inflamm. Res. (2024). https://doi.org/10.1007/s00011-024-01879-4

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