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The interrelation of osteoarthritis and diabetes mellitus: considering the potential role of interleukin-10 and in vitro models for further analysis

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Abstract

Introduction

Today, not only the existence of an interrelation between obesity/adipositas and osteoarthritis (OA) but also the association of OA and diabetes mellitus (DM) are widely recognized. Nevertheless, shared influence factors facilitating OA development in DM patients still remain speculative up until now. To supplement the analysis of clinical data, appropriate in vitro models could help to identify shared pathogenetic pathways. Informative in vitro studies could later be complemented by in vivo data obtained from suitable animal models.

Materials and methods

Therefore, this detailed review of available literature was undertaken to discuss and compare the results of currently published in vitro studies focusing on the interrelation between OA, the metabolic syndrome and DM and to propose models to further study the molecular pathways.

Results

The survey of literature presented here supports the hypothesis that the pathogenesis of OA in DM is based on imbalanced molecular pathways with a putative crucial role of antiinflammatory cytokines such as IL-10.

Conclusion

Future development of versatile micro-scaled in vitro models such as combining DM and OA on chip could allow the identification of common pathogenetic pathways and might help to develop novel therapeutic strategies.

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Abbreviations

ACL:

Anterior cruciate ligament

AGE:

Advanced glycation end products

BMI:

Body mass index

BMP:

Bone morphogenetic protein

CRP:

C-reactive protein

2D/3D:

Two/three dimensional

DM:

Diabetes mellitus

DMEM:

Dulbecco’s modified Eagles medium

ECM:

Extracellular matrix

ERK1/2:

Extracellular signal regulated kinase 1/2

FBS:

Fetal bovine serum

FFA:

Free fatty acids

GAG:

Glycosaminoglycans

2-DG:

2-Deoxy-d-glucose

GLU-1-3:

Glucose transporter 1-3

HO-1:

Hemoxygenase-1

IGF:

Insulin-like growth factor

IGFR-1:

Insulin-like growth factor receptor 1

IL:

Interleukin

iNOS:

Inducible nitric oxide

InsR:

Insulin receptor

IR:

Insulin resistance

LC3 II:

Lipid-modified microtubule-associated light chain 3 protein

MMP:

Matrix metalloproteinase

MSC:

Mesenchymal stromal cell

NO:

Nitric oxide

OA:

Osteoarthritis

PCL:

Posterior cruciate ligament

PGE2:

Prostaglandine E2

PLGA:

Polylactic glycolic acid

PPARα, γ:

Peroxisome proliferator-activated receptor α, γ

PI3K:

Phosphoinositide 3-kinase

RAGE:

Receptor of AGE

ROS:

Reactive oxygen species

RPMI medium:

Roswell Park Memorial Institute medium

SMAD1/5/8:

Small body size/mothers against decapentaplegic 1/5/8

STAT3:

Signal transducer and activator of transcription

TNF:

Tumor necrosis factor

T1DM:

Type 1 diabetes mellitus

T2DM:

Type 2 diabetes mellitus

VAS:

Visual analogue scale

VEGF:

Vascular endothelial growth factor

WOMAC:

Western Ontario and McMaster Universities Arthritis Index

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Acknowledgements

The authors are grateful for financial support by the Kerscher foundation. They are also grateful for the support of Mr. Benjamin Kohl, Carola Meier and Jessica Badendick (Dep. of Trauma and Reconstructive Surgery, CBF, Charité-Berlin).

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    Authors and Affiliations

    1. Department of Anatomy, Paracelsus Medical University, Prof. Ernst Nathan Str. 1, 90419, Nuremberg, Germany

      Silke Schwarz, Sandeep Silawal & Gundula Schulze-Tanzil

    2. Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria

      Silke Schwarz, Sandeep Silawal & Gundula Schulze-Tanzil

    3. MVZ Limbach Laboratories, Aroser Allee 84, 13407, Berlin, Germany

      Ingo Mrosewski

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    1. Silke Schwarz
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    Correspondence to Gundula Schulze-Tanzil.

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    Silke Schwarz and Ingo Mrosewski contributed equally to this work.

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    Schwarz, S., Mrosewski, I., Silawal, S. et al. The interrelation of osteoarthritis and diabetes mellitus: considering the potential role of interleukin-10 and in vitro models for further analysis. Inflamm. Res. 67, 285–300 (2018). https://doi.org/10.1007/s00011-017-1121-8

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