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The role of mast cells in ischemia and reperfusion injury

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Abstract

Introduction

Ischemia and reperfusion (IR) injury is a challenging clinical problem that is triggered by ischemia in an organ followed by subsequent restoration of the blood supply. The effects of mast cell (MC) in IR injury are not totally clear.

Materials and methods

We review the body of literature on the role of MCs in IR injury based on an unrestricted Pubmed search for the descriptors "mast cell", "ischemia" and "reperfusion injury", as well as discuss implications for treatment and future directions.

Results

Shortly after IR, chemicals released by MC can trigger vasoactive substance formation, tissue leakage, upregulation of adhesive molecules followed by leukocyte recruitment and infiltration, and pronecrotic pathway activation, among other physiologic changes. In the long term, MCs may influence tissue remodeling and repair as well as blood restoration after IR. Consistent with these findings, methods and drugs that target MCs have been shown to attenuate IR injury.

Conclusion

It has been demonstrated that MCs play a role in IR injury, but the mechanisms are complex and need to be further studied.

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Acknowledgments

This work is supported by the National Natural Funds of China (NO. 81270555); Program for New Century Excellent Talents in University, No. NCET-13-0422; “Shu Guang Scholar” Project, Shanghai Municipal Educational Commission, No. 10SG20; the Key Medical Project of Science and Technology Commission Shanghai Municipality, No. 09411952500.

Conflict of interest

The authors declare that they have no competing financial interests.

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  1. Department of General Surgery, Shanghai Tenth People’s Hospital, Tongji University, 301 Middle Yanchang Road, Shanghai, 200072, China

    Mu-qing Yang, Yuan-yuan Ma, Jing Ding & Ji-yu Li

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  1. Mu-qing Yang
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Yang, Mq., Ma, Yy., Ding, J. et al. The role of mast cells in ischemia and reperfusion injury. Inflamm. Res. 63, 899–905 (2014). https://doi.org/10.1007/s00011-014-0763-z

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