Skip to main content
SpringerLink
Log in

Enantiomeric separation of three chiral drugs by nonaqueous capillary electrophoresis with triethylamine as additive

  • Short Communication
  • Published:
Chromatographia Aims and scope Submit manuscript

Summary

The enantiomeric separation of chiral drugs by capillary electrophoresis (CE) in nonaqueous system has been investigated. Successful separation of bepridil, ondansetron and pinacidil in formamide using β-cyclodextrin as chiral selector were achieved. The addition of triethylamine into the background electrolyte enhanced the enantiomeric discrimination.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Y. Walbroehl, J.W. Jorgenson, J. Chromatogr. A.315, 135 (1984).

    Article  CAS  Google Scholar 

  2. I.E. Valko, H. Siren, M.L. Riekkola, LC-GC,15, 560 (1997).

    CAS  Google Scholar 

  3. S.H. Hansen, J. Tjornelund, I. Bjornsdottir, TrAC,15, 175 (1996).

    CAS  Google Scholar 

  4. I.E. Valko, H. Siren, M.-L. Riekkola, J. Chromatogr. A,737, 263 (1996).

    Article  CAS  Google Scholar 

  5. Y. Mori, K. Ueno, T. Umeda, J. Chromatogr. A,757, 328 (1997).

    Article  CAS  Google Scholar 

  6. I.E. Valko, H. Siren, M.-L. Riekkola Electrophoresis,18, 919 (1997).

    Article  CAS  Google Scholar 

  7. A.M. Stalcup, K.H. Gahm, J. Microcolumn Sep,8, 145 (1996).

    Article  CAS  Google Scholar 

  8. F. Wang, M.G. Khaledi, Anal. Chem,68, 3460 (1996).

    Article  CAS  Google Scholar 

  9. I. Bjornsdottir, S.H. Hansen, S. Terabe, J. Chromatogr. A,745, 37 (1996).

    Article  CAS  Google Scholar 

  10. F. Wang, M.G. Khaledi, J. Chromatogr. A,817, 121 (1998).

    Article  CAS  Google Scholar 

  11. J.B. Vincent, G. Vigh, J. Chromatogr. A,816, 233 (1998).

    Article  CAS  Google Scholar 

  12. J.J. Chen, I.M. Londen, Cell,26, 117 (1981).

    Article  CAS  Google Scholar 

  13. L. Ye, J.T. Stewart, J. Liq. Chromatogr. A,19, 711 (1996).

    CAS  Google Scholar 

  14. Z. Wang, A. Huang, Y. Sun, J. Chromatogr. A,749, 300 (1996).

    Article  CAS  Google Scholar 

  15. P. Corradini, A. Rhomberg, C. Corradini, J. Chromatogr. A,661, 305 (1994).

    Article  CAS  Google Scholar 

  16. V. Rohlicek, Z. Deyl, J. Chromatogr. A494, 87 (1988).

    Google Scholar 

  17. Y. Dong, Y. Sun, Z. Sun, J. HRC,21, 445 (1998).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Peking University, 100871, Beijing, P.R. China

    Xueqin Ren, Aijin Huang, Tiansong Wang & Yiliang Sun

  2. National Institute for the Control of Pharmaceutical and Biological Products, 100050, Beijing, P.R. China

    Zengpei Sun

Authors
  1. Xueqin Ren
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Aijin Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tiansong Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yiliang Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zengpei Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ren, X., Huang, A., Wang, T. et al. Enantiomeric separation of three chiral drugs by nonaqueous capillary electrophoresis with triethylamine as additive. Chromatographia 50, 625–628 (1999). https://doi.org/10.1007/BF02493671

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02493671

Key Words

Search

Navigation