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Hypergranular acute lymphoblastic leukemia (ALL)

Report of a case and review of the literature

  • Case Report
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Summary

We report a case of adult acute lymphoblastic leukemia (ALL) with myeloid-like hypergranulation of blast cells. Like most of the “granular” ALLs described in the literature, the blast cells had L2 morphology and exhibited a common-ALL immunologic phenotype. The clinical findings at diagnosis were unremarkable. Cytogenetic analysis showed a 46XY karyotype. Molecular genetic analysis revealed T-cell receptor (TCR)γ and immunoglobulin heavy chain rearrangements; no rearrangement was found at the TCRβ gene locus. The polymerase chain reaction (PCR) for the BCR-ABL translocation was negative. The clinical course of the patient was uncomplicated. On standard ALL treatment protocol he achieved complete remission (CR) within 4 weeks, and he is currently disease free 8 months after diagnosis. The case contributes well-documented data to the characterization of adult “granular” ALL, with special regard to changes at the molecular genetic level.

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Authors and Affiliations

  1. Clinical Institute for Medical and Chemical Laboratory Diagnosis, University of Vienna, Austria

    I. Schwarzinger, M. Födinger, Ch. Mannhalter & W. Speiser

  2. First Medical Clinic, Division of Hematology and Blood Coagulation, University of Vienna, Austria

    R. Scherrer & M. Wolzt

Authors
  1. I. Schwarzinger
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  2. M. Födinger
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  3. R. Scherrer
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  4. M. Wolzt
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  5. Ch. Mannhalter
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  6. W. Speiser
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Schwarzinger, I., Födinger, M., Scherrer, R. et al. Hypergranular acute lymphoblastic leukemia (ALL). Ann Hematol 67, 301–303 (1993). https://doi.org/10.1007/BF01696351

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  • DOI: https://doi.org/10.1007/BF01696351

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