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Oxazepines and thiazepines. XIX Synthesis of optically active 2,3-dihydro-1,5-benzothiazepin-4(5H)-ones

Oxazepine und Thiazepine, 19. Mitt.: Synthese optisch aktiver 2,3-Dihydro-1,5-benzothiazepin-4(5H)-one

  • Organische Chemie Und Biochemie
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Abstract

Optically active 2,3-dihydro-1,5-benzothiazepin-4(5H)-ones (14–17) have been synthesizedvia resolution and chemical transformation of nitrocarboxylic acids6–9. Starting from the latter various optically active substances have been synthesized as well. Optical purity was checked by NMR spectroscopy.

Zusammenfassung

Optisch aktive 2,3-Dihydro-1,5-benzothiazepin-4(5H)-one (14–17) wurden mittels Racematspaltung und weiterer chemischer Umsetzungen der Nitrocarbonsäuren6–9 hergestellt. Ausgehend von optisch aktiven Carbonsäuren wurden außerdem verschiedene optisch aktive Verbindungen synthetisiert. Die optische Reinheit wurde mit Hilfe der NMR-Spektroskopie überprüft.

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Authors and Affiliations

  1. Lehrstuhl für Strukturchemie, Ruhruniversität, D-4630, Bochum, Federal Republic of Germany

    Gisbert Puzicha

  2. Department of Organic Chemistry, Lajos Kossuth University, H-4010, Debrecen, Hungary

    Albert Lévai & László Szilágyi

Authors
  1. Gisbert Puzicha
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  2. Albert Lévai
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  3. László Szilágyi
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Dedicated to Prof. Dr.G. Snatzke on the occasion of his 60th birthday.

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Puzicha, G., Lévai, A. & Szilágyi, L. Oxazepines and thiazepines. XIX Synthesis of optically active 2,3-dihydro-1,5-benzothiazepin-4(5H)-ones. Monatsh Chem 119, 933–944 (1988). https://doi.org/10.1007/BF00810103

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  • DOI: https://doi.org/10.1007/BF00810103

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