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Alkaloids from Marine Ascidians (Tunicates) and Potential for Cancer Drug Development

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Marine Niche: Applications in Pharmaceutical Sciences

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Abstract

Tunicates are deliberated to be a rich source of alkaloids, with unique and diverse chemical structures. There are a number of alkaloids derived from marine ascidians and reported to have a variety of pharmacological activities. More than 300 such alkaloids from ascidians have been reported across the globe. In recent years, cancer has become a complicated disease encountered by developing and developed countries around the world. The marine ascidian-derived alkaloids play a potential role in cancer and other diseases. So far, two ascidian-derived alkaloid compounds are commercially available and employed as drugs for the treatment of various cancer in the USA. In other countries, few compounds are under clinical and preclinical trials. This chapter provides detailed information on alkaloids from marine ascidians and the development of these as a promising application in future as anticancer drugs.

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Acknowledgment

This work was financially supported by the CSIR-SRF, New Delhi.

Conflict of the Interest

All authors have the no conflict interest.

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Authors and Affiliations

  1. Department of Medical Biotechnology, Chettinad Academy of Research and Education, Kelambakkam, Chennai, Tamil Nadu, India

    Manigandan Venkatesan, Nishakavya Saravanan & Saravanan Ramachandran

  2. Department of Biotechnology, BIT Campus, Anna University, Tiruchirappalli, Tamil Nadu, India

    Selvakumar Murugesan

  3. Department of Animal Science, Centre for Pheromone Technology, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India

    Rathinam Ayyasamy

  4. Department of Medicine, University of Texas Health Science Center, San Antonio, USA

    Karthik Ramachandran

  5. Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India

    Velusamy Arumugam

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Editors and Affiliations

  1. Department of Science & Technology, Gujarat Biotechnology Research Centre (GBRC), Gandhinagar, Gujarat, India

    Neelam M Nathani

  2. Department of Science & Technology, Gujarat Biotechnology Research Centre (GBRC), Gandhinagar, Gujarat, India

    Chandrashekar Mootapally

  3. Department of Life Sciences, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar, Gujarat, India

    Indra R. Gadhvi

  4. Department of Botany, Gujarat University, Ahmedabad, Gujarat, India

    Bharat Maitreya

  5. Department of Science & Technology, Gujarat Biotechnology Research Centre (GBRC), Gandhinagar, Gujarat, India

    Chaitanya G. Joshi

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Venkatesan, M. et al. (2020). Alkaloids from Marine Ascidians (Tunicates) and Potential for Cancer Drug Development. In: Nathani, N.M., Mootapally, C., Gadhvi, I.R., Maitreya, B., Joshi, C.G. (eds) Marine Niche: Applications in Pharmaceutical Sciences . Springer, Singapore. https://doi.org/10.1007/978-981-15-5017-1_15

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