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Tunicates: A Vertebrate Ancestral Source of Antitumor Compounds

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Handbook of Anticancer Drugs from Marine Origin

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Abstract

An alarming increase in cancer deaths around the globe has sparked a quest for new effective antitumor drugs developed through biological screening of both terrestrial and marine organisms. Recently, analyses of marine-derived alkaloids isolated from tunicates, a close relative to vertebrates, reveal various anti-cancer activities including anti-angiogenic action, anti-proliferative activity, inhibition of key cellular events like topoisomerase function and tubulin polymerization with respect to cytotoxicity and apoptosis . Vast numbers of potential anticancer molecules in the marine biosphere cannot be underestimated. Tunicate compounds have already entered the market and shown significant success. Moreover, improved technology has enabled synthesis of these molecules by a diverse cadre of professionals including career biologists, immunobiologists, invertebrate immunologists, and marine biologists who use an amazing array of procedures. Although there are no guarantees of consistently reliable success, identifying and comprehending the basic nature of these compounds is a promising first step towards unique pharmaceutical designs that promise to provide a therapeutic solution.

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References

  1. University of California Museum of Paleontology (2006) Introduction to the Urochordata. http://www.ucmp.berkeley.edu/chordata/urochordata.html. Accessed 29 Sept 2013

  2. Cooper EL (2012) Adaptive immunity from prokaryotes to eukaryotes: broader inclusions due to less exclusivity? In: Kanwar JR (ed) Recent advances in immunology to target cancer, inflammation and infections. Tech, Croatia, pp 495–520

    Google Scholar 

  3. Parrinello N (1996) Cytotoxic activity of tunicate hemocytes. Prog Mol Subcell Biol 15:190–217

    Article  CAS  Google Scholar 

  4. Cooper EL, Yao D (2012) Diving for drugs: tunicate anticancer compounds. Drug Discov Today 17(11–12):636–648

    Article  CAS  Google Scholar 

  5. Robert J (2010) Comparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebrates. Dev Comp Immunol 34(9):915–925

    Article  CAS  Google Scholar 

  6. Kvell K, Cooper EL, Engelmann P et al (2007) Blurring borders: innate immunity with adaptive features. Clin Dev Immunol. http://www.hindawi.com/journals/jir/2007/083671/abs/

  7. Cooper EL, Mansour MH, Negm HI (1996) Marine invertebrate immunodefense responses: molecular and cellular approaches in tunicates. Annu Rev Fish Dis 6:133–149

    Article  Google Scholar 

  8. Cooper EL, Parrinello N (2001) Immunodefense in tunicates: cells and molecules. In: The biology of ascidians. Springer, Tokyo, pp 383–391

    Book  Google Scholar 

  9. Morandi A, Tosto C, Sartori G, Roberti di Sarsina P (2011) Advent of a link between ayurveda and modern health science: the proceedings of the first international congress on ayurveda, Ayurveda: the meaning of life-awareness, environment, and health March 21–22, 2009, Milan, Italy. Evid Based Complement Alternat Med 2011:929–083

    Article  Google Scholar 

  10. Liu ML, Chien LY, Tai CJ, Lin KC (2011) Effectiveness of traditional Chinese medicine for liver protection and chemotherapy completion among cancer patients. Evid Based Complement Alternat Med 2011:291–843

    Google Scholar 

  11. Watanabe K, Matsuura K, Gao P, Hottenbacher L, Tokunaga H, Nishimura K, Imazu Y, Reissenweber H, Witt CM (2011) Traditional Japanese kampo medicine: clinical research between modernity and traditional medicine-the state of research and methodological suggestions for the future. Evid Based Complement Alternat Med 2011:513–842

    Article  Google Scholar 

  12. Cooper EL, Balamurugan M (2010) Unearthing a source of medicinal molecules. Drug Discov Today 15(21):966–972

    Article  Google Scholar 

  13. Cooper EL (2005) CAM, eCAM, bioprospecting: the twenty first century pyramid. Evid Based Complement Alternat Med 2(2):125

    Article  Google Scholar 

  14. Rinehart KL (2000) Antitumor compounds from tunicates. Med Res Rev 20(1):1–27

    Article  CAS  Google Scholar 

  15. Sima P, Vetvicka V (2011) Bioactive substances with anti-neoplastic efficacy from marine invertebrates: bryozoa, Mollusca, Echinodermata and Urochordata. World J Clin Oncol 2(11):362

    Article  Google Scholar 

  16. Tohme R, Darwiche N, Gali-Muhtasib H (2011) A journey under the sea: the quest for marine anti-cancer alkaloids. Molecules 16(12):9665–9696

    Article  CAS  Google Scholar 

  17. Mayer A (2013) Marine pharmaceuticals: the preclinical pipeline. http://marinepharmacology.midwestern.edu/preclinPipeline.htm. Accessed 15 Oct 2013

  18. Tulp M, Bohlin L (2002) Functional versus chemical diversity: is biodiversity important for drug discovery? Trends Pharmacol Sci 23(5):225–231

    Article  CAS  Google Scholar 

  19. Haefner B (2003) Drugs from the deep: marine natural products as drug candidates. Drug Discov Today 8(12):536–544

    Article  CAS  Google Scholar 

  20. NOAA Central Library (2013) Sea squirt. http://www.lib.noaa.gov/retiredsites/korea/main_species/sea_squirt.htm. Accessed 29 Oct 2013

  21. Kim SM (2011) Antioxidant and anticancer activities of enzymatic hydrolysates of solitary tunicate (Styela clava). Food Sci Biotechnol 20(4):1075–1085

    Article  Google Scholar 

  22. Ryan JT, Ross RP, Bolton D et al (2011) Bioactive peptides from muscle sources: meat and fish. Nutrients 3(9):765–791

    Article  CAS  Google Scholar 

  23. Suarez-Jimenez GM, Burgos-Hernandez A, Ezquerra-Brauer JM (2012) Bioactive peptides and depsipeptides with anticancer potential: sources from marine animals. Mar Drugs 10(5):963–986

    Article  CAS  Google Scholar 

  24. Cooper EL (2010) eCAM: retaining an international perspective. Evid Based Complement Alternat Med 7(4):397

    Article  Google Scholar 

  25. Goldrosen MH, Straus SE (2004) Complementary and alternative medicine: assessing the evidence for immunological benefits. Nat Rev Immunol 4:912–921

    Article  CAS  Google Scholar 

  26. Jimenez PC, Wilke DV, Takeara R et al (2008) Cytotoxic activity of a dichloromethane extract and fractions obtained from Eudistoma vannamei (Tunicata: Ascidiacea). Comp Biochem Physiol A Mol Integr Physiol 151(3):391–398

    Article  Google Scholar 

  27. Takeara R, Jimenez PC, Wilke DV et al (2008) Antileukemic effects of Didemnum psammatodes (Tunicata: Ascidiacea) constituents. Comp Biochem Physiol A Mol Integr Physiol 151(3):363–369

    Article  Google Scholar 

  28. Sung PJ, Lin MR, Chen JJ et al (2007) Hydroperoxysterols from the tunicate Eudistoma sp. Chem Pharm Bull 55(4):666–668

    Article  CAS  Google Scholar 

  29. Fedorov SN, Radchenko OS, Shubina LK et al (2006) Evaluation of cancer-preventive activity and structure–activity relationships of 3-demethylubiquinone Q2, isolated from the ascidian Aplidium glabrum, and its synthetic analogs. Pharm Res 23(1):70–81

    Article  CAS  Google Scholar 

  30. Rashid MA, Gustafson KR, Boyd MR (2001) New cytotoxic N-methylated beta-carboline alkaloids from the marine ascidian Eudistoma gilboverde. J Nat Prod 64(11):1454–1456

    Article  CAS  Google Scholar 

  31. Oda T, Kamoshita K, Maruyama S et al (2007) Cytotoxicity of lissoclibadins and lissoclinotoxins, isolated from a tropical ascidian Lissoclinum cf. badium, against human solid-tumor-derived cell lines. Biol Pharm Bull 30(2):385–387

    Article  CAS  Google Scholar 

  32. Manzanares I, Cuevas C, Garcia-Nieto R et al (2001) Advances in the chemistry and pharmacology of ecteinascidins, a promising new class of anticancer agents. Curr Med Chem Anticancer Agent 1(3):257–276

    Article  CAS  Google Scholar 

  33. Urdiales J, Morata P, De Castro IN, Sánchez-Jiménez F (1996) Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates. Cancer lett 102(1):31–37

    Article  CAS  Google Scholar 

  34. Appleton DR, Page MJ, Lambert G et al (2002) Kottamides AD: novel bioactive imidazolone-containing alkaloids from the New Zealand ascidian Pycnoclavella kottae. J Org Chem 67(15):5402–5404

    Article  CAS  Google Scholar 

  35. Xu CX, Jin H, Chung YS et al (2008) Chondroitin sulfate extracted from ascidian tunic inhibits phorbol ester-induced expression of inflammatory factors VCAM-1 and COX-2 by blocking NF-κB activation in mouse skin. J Agric Food Chem 56(20):9667–9675

    Article  CAS  Google Scholar 

  36. Depenbrock H, Peter R, Faircloth GT, Manzanares I, Jimeno J, Hanauske AR (1998) In vitro activity of aplidine, a new marine-derived anti-cancer compound, on freshly explanted clonogenic human tumour cells and haematopoietic precursor cells. Br J Cancer 78(6):739

    Article  CAS  Google Scholar 

  37. Reichardt P (2013) Current questions in soft tissue sarcoma: further steps with Yondelis®. Expert Rev Anticancer Ther 13:25–30

    Article  Google Scholar 

  38. Le Tourneau C, Raymond E, Faivre S (2007) Aplidine: a paradigm of how to handle the activity and toxicity of a novel marine anticancer poison. Curr Pharm Des 13(33):3427–3439

    Article  CAS  Google Scholar 

  39. Monk BJ, Herzog TJ, Kaye S et al (2010) Trabectedin plus pegylated liposomal doxorubicin in recurrent ovarian cancer. J Clin Oncol 28(19):3107–3114

    Article  CAS  Google Scholar 

  40. Twelves C, Hoekman K, Bowman A et al (2003) Phase I and pharmacokinetic study of Yondelis™(ecteinascidin-743; ET-743) administered as an infusion over 1 h or 3 h every 21 days in patients with solid tumours. Eur J Cancer 39(13):1842–1851

    Article  CAS  Google Scholar 

  41. D’Incalci M, Jimeno J (2003) Preclinical and clinical results with the natural marine product ET-743. Expert Opin Investig Drugs 12:1843–1853

    Article  Google Scholar 

  42. Schöffski P, Dumez H, Wolter P et al (2008) Clinical impact of trabectedin (ecteinascidin-743) in advanced/metastatic soft tissue sarcoma. Expert Opin Pharmacother 9:1609–1618

    Article  Google Scholar 

  43. Poveda A (2011) Introduction. Int J of Gynecol Cancer 21(10):S1–S2

    Article  Google Scholar 

  44. Xu Y, Kersten RD, Nam SJ et al (2012) Bacterial biosynthesis and maturation of the didemnin anti-cancer agents. J Am Chem Soc 134(20):8625–8632

    Article  CAS  Google Scholar 

  45. Baker DD, Alvi KA (2004) Small-molecule natural products: new structures, new activities. Curr Opin Biotechnol 15:576–583

    Article  CAS  Google Scholar 

  46. Tsukimoto M, Nagaoka M, Shishido Y et al (2011) Bacterial production of the tunicate-derived antitumor cyclic depsipeptide didemnin B. J Nat Prod 74(11):2329–2331

    Article  CAS  Google Scholar 

  47. Carter NJ, Keam SJ (2010) Trabectedin: a review of its use in soft tissue sarcoma and ovarian cancer. Drugs 70:355–376

    CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Laboratory of Comparative Neuroimmunology, Department of Neurobiology, David Geffen School Of Medicine at UCLA, University of California, 90095-1763, Los Angeles, CA, USA

    Edwin L. Cooper & Ralph Albert

Authors
  1. Edwin L. Cooper
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  2. Ralph Albert
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Corresponding author

Correspondence to Edwin L. Cooper .

Editor information

Editors and Affiliations

  1. Department of Marine-Bio Convergence Science, Pukyong National University, Busan, Korea, Republic of (South Korea)

    Se-Kwon Kim

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Cooper, E., Albert, R. (2015). Tunicates: A Vertebrate Ancestral Source of Antitumor Compounds. In: Kim, SK. (eds) Handbook of Anticancer Drugs from Marine Origin. Springer, Cham. https://doi.org/10.1007/978-3-319-07145-9_18

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