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Nano-Particles for Biomedical Applications

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Springer Handbook of Nanotechnology

Part of the book series: Springer Handbooks ((SHB))

Abstract

Nanoparticles (GlossaryTerm

NP

s) are extremely small particulates with an average size that ranges from a micron or less to a few nanometers. The large majority of NPs necessitate nanotechnology methods for their production. The size of NPs may vary over a significant range, which underlies their scientific potential in that NPs may help cross the bridge between bulk materials and molecular structures. More importantly, NPs are (nano)tech products and thus, in contrast to natural systems, they can be designed and engineered. On directly interacting with cells, including the structures of cells, their machinery and their waste products, NPs represent an unprecedented tool for addressing specific biological problems. In this chapter, we will briefly review some recent advances in nanoparticle research for biomedical applications, ranging from mesoporous silicon particles to gold and silver nanoparticles and polymeric nanocarriers for therapeutic, diagnosis, or theranostic (therapeutics + diagnosis) applications. We will offer a description of how, at the current state of the art, similar nanomedicine platforms are realized.

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Acknowledgements

Dr. Hélder A. Santos acknowledges the Academy of Finland (project numbers 252215 and 281300), the University of Helsinki and the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC Grant agreement number 310892 for financial support. Dr. Dongfei Liu and Dr. Bárbara Herranz Blanco (Division of Pharmaceutical Chemistry and Technology) are also acknowledged for their discussions and for providing some of the material in the microfluidics section. Professor Francesco Gentile acknowledges the Italian Minister of Health (Project number GR-2010-2320665).

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Authors and Affiliations

  1. Laboratory of Nanotechnology for Precision Medicine, Italian Institute of Technology, Via Morego 30, 16163, Genova, Italy

    Paolo Decuzzi, Alessandro Coclite, Anna Lisa Palange & Daniele Di Mascolo

  2. International Research Organization for Advanced Science and Technology, Kumamoto University, 2-31-1 Kurokami, Chuo-ku, 860-8555, Kumamoto, Japan

    Aeju Lee

  3. Craniofacial Development and Stem Cell Biology, King‘s College London, Guy‘s Hospital, 27th Floor Tower Wing, SE1 9RT, London, UK

    Ciro Chiappini

  4. Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Viikinkaari 5E, 00790, Helsinki, Finland

    Hélder A. Santos

  5. Dept. of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Viale Europa, loc. Germaneto, 88100, Catanzaro, Italy

    Maria Laura Coluccio, Gerardo Perozziello & Patrizio Candeloro

  6. Dept. of Physical Science and Engineering, King Abdullah University of Science and Technology, Bldg. 2 (Ibn Al-Haytham) 4th floor, Office #4220 Red Sea side, 23955-6900, Thuwal, Saudi Arabia

    Enzo Di Fabrizio

  7. Dept. of Electrical Engineering and Information Technology, University Naples Federico II, Via Claudio 21, 80125, Naples, Italy

    Francesco Gentile

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  1. Paolo Decuzzi
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Decuzzi, P. et al. (2017). Nano-Particles for Biomedical Applications. In: Bhushan, B. (eds) Springer Handbook of Nanotechnology. Springer Handbooks. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54357-3_21

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