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Acetogenic Bacteria for Biotechnological Applications

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Enzymes for Solving Humankind's Problems

Abstract

Acetogenic bacteria are a group of strictly anaerobic bacteria that employ the Wood–Ljungdahl pathway to reduce two molecules of CO2 to acetyl-CoA, the central intermediate to various chemical compounds such as acetate, ethanol or butyrate. The capability of acetogens to utilize a wide range of substrates including industrial waste gas, methanol, formate and CO has led to a tremendous interest over the last decade to use them as industrial platform organisms to produce these valuable chemical compounds. In addition, some acetogens also possess a unique enzyme complex that directly reduces CO2 to formate with H2 as electron donor. This complex is superior over any chemical catalyst in hydrogenation of CO2 and, therefore, these acetogens are also promising candidates for storage or production of hydrogen as well as carbon capture and storage. In this chapter, we discuss the biochemistry of acetogenic bacteria and give an overview of highlighted acetogenic organisms with respect to their biotechnical applications. Moreover, we discuss the progress that has been made in the development of metabolically engineered acetogens as biocatalysts for the production of valuable compounds such as acetone or biopolymers.

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Authors and Affiliations

  1. Molecular Microbiology and Bioenergetics, Institute of Molecular Biosciences, Johann Wolfgang Goethe University Frankfurt/Main, Frankfurt, Germany

    Dennis Litty & Volker Müller

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  1. Dennis Litty
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  2. Volker Müller
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Correspondence to Volker Müller .

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  1. LAQV, REQUIMTE, NOVA School of Science and Technology, Caparica, Portugal

    José J. G. Moura

  2. LAQV, REQUIMTE, NOVA School of Science and Technology, Caparica, Portugal

    Isabel Moura

  3. LAQV, REQUIMTE, NOVA School of Science and Technology, Caparica, Portugal

    Luisa B. Maia

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Litty, D., Müller, V. (2021). Acetogenic Bacteria for Biotechnological Applications. In: Moura, J.J.G., Moura, I., Maia, L.B. (eds) Enzymes for Solving Humankind's Problems. Springer, Cham. https://doi.org/10.1007/978-3-030-58315-6_4

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