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Migraine Is More Than “Just a Headache”

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Discussing Migraine With Your Patients

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Abstract

Migraine is always more than a headache. Migraine is comorbid with many common conditions including, depression, anxiety, bipolar disorder, insomnia, fibromyalgia, and epilepsy. Migraineurs have increased risk for cardiovascular disease. Migraine also creates difficulties with familial and social functioning when family, friends, and the workplace do not understand migraine.

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References

  1. Calhoun AH, Ford S, Millen C, Finkel AG, Truong Y, Nie Y. The prevalence of neck pain in migraine. Headache. 2010;50:1273–7.

    Article  PubMed  Google Scholar 

  2. Calhoun AH, Ford S, Pruitt AP. Presence of neck pain may delay migraine treatment. Postgrad Med. 2011;123:163–8.

    Article  PubMed  Google Scholar 

  3. Ford S, Calhoun A, Kahn K, Mann J, Finkel A. Predictors of disability in migraineurs referred to a tertiary clinic: neck pain, headache characteristics, and coping behaviors. Headache. 2008;48:523–8.

    Article  PubMed  Google Scholar 

  4. Buse DC, Loder EW, Gorman JA, Stewart WF, Reed ML, Fanning KM, et al. Sex differences in the prevalence, symptoms, and associated features of migraine, probably migraine and other severe headache: results of the American Migraine Prevalence and Prevention (AMPP) Study. Headache. 2013;53(8):1278–99.

    Article  PubMed  Google Scholar 

  5. Silberstein SD. Migraine symptoms: results of a survey of self-reported migraineurs. Headache. 1995;35:387–96.

    Article  CAS  PubMed  Google Scholar 

  6. Calhoun AH, Ford S, Pruitt AP, Fisher KG. The point prevalence of dizziness or vertigo in migraine–and factors that influence presentation. Headache. 2011;51:1388–92.

    Article  PubMed  Google Scholar 

  7. Scher AI, Bigal ME, Lipton RB. Comorbidity of migraine. Curr Opin Neurol. 2005;18:305–10.

    Article  PubMed  Google Scholar 

  8. Low NC, Merikangas KR. The comorbidity of migraine. CNS Spectr. 2003;8:433–44.

    Article  PubMed  Google Scholar 

  9. Nicodemo M, Cevoli S, Gianni G, Cortelli P. Comorbidity in perimenstrual migraine. Curr Pain Headache Rep. 2012;16:477–83.

    Article  PubMed  Google Scholar 

  10. Cevoli S, Giannini G, Favoni V, Pierangeli G, Cortelli P. Migraine and sleep disorders. Neurol Sci. 2012;33 suppl 1:S43–6.

    Article  PubMed  Google Scholar 

  11. Mehle ME. Migraine and allergy: a review and clinical update. Curr Allergy Asthma Rep. 2012;12:240–5.

    Article  PubMed  Google Scholar 

  12. Walters AB, Harner JD, Smitherman TA. Sleep disturbance and affective comorbidity among episodic migraineurs. Headache. 2014;54(1):116–24.

    Article  PubMed  Google Scholar 

  13. Kurth T, Gaziano JM, Cook NR. Migraine risk of cardiovascular disease in women. JAMA. 2006;296:283–92.

    Article  CAS  PubMed  Google Scholar 

  14. Bigal ME, Kurth T, Santanello N, Buse D, Golden W, Robbins M, et al. Migraine and cardiovascular disease. A population-based study. Neurology. 2010;74:628–35.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Spector JT, Kahn SR, Jones MR, Jayakumar M, Dalal D, Nazarian S. Migraine headache and ischemic stroke risk: an updated meta-analysis. Am J Med. 2010;123:612–24.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Alhazzani A, Goddeau RP. Migraine and stroke: a continuum of association in adults. Headache. 2013;53(6):1023–7.

    Article  PubMed  Google Scholar 

  17. Kurth T, Bubes V, Buring J. Relative contribution of migraine with aura to cardiovascular disease occurrence in women. Presented at the American Academy of Neurology, San Diego, March 2013. Available at http://www.neurology.org/cgi/content/meeting_abstract/80/1_MeetingAbstracts/S40.001?sid=b4e2e84d-5c7e-4f00-984a-fb99ee445108. Accessed Apr 2013.

  18. Buse DC, Silberstein SD, Manack AN, Papapetropoulos S, Lipton RB. Psychiatric comorbidities of episodic and chronic migraine. J Neurol. 2013;260(8):1960–9.

    Article  PubMed  Google Scholar 

  19. Schur EA, Noonan C, Buchwald D, Goldberg J, Afari N. A Twin study of depression and migraine: evidence for a shared genetic vulnerability. Headache. 2009;49:1493–502.

    Article  PubMed  Google Scholar 

  20. Liqthart L, Nyholt DR, Penninx BW, Boomsma DI. The shared genetics of migraine and anxious depression. Headache. 2010;50:1549–60.

    Article  Google Scholar 

  21. Ashina S, Serrano D, Lipton RB, et al. Depression and risk of transformation of episodic to chronic migraine. J Headache Pain. 2012;13:615–24.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Kroenke K, Spitzer RL, Williams JW, Löwe B. An ultra-brief screening scale for anxiety and depression: the PHQ-4. Psychosomatics. 2009;50:613–21.

    PubMed  Google Scholar 

  23. Löwe B, Wahl I, Rose M, Spitzer C, Glaesmer H, Wingenfeld K, et al. A 4-item measure of depression and anxiety: validation and standardization of the Patient Health Questionnaire-4 (PHQ-4) in the general population. J Affect Disord. 2010;122:86–95.

    Article  PubMed  Google Scholar 

  24. Peterlin BL, Tietjen GE, Gower BA, Ward TN, Tepper SJ, White LW, et al. Ictal adiponectin levels in episodic migraineurs: a randomized pilot trial. Headache. 2013;53:474–90.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Giraud P, Chauvet S. Migraine obesity, is there a link? Rev Neurol (Paris). 2013;169:413–8.

    Article  CAS  Google Scholar 

  26. Vo M, Ainalem A, Qui C, Peterlin BL, Aurora SK, Williams MA. Body mass index and adult weight gain among reproductive age women with migraine. Headache. 2011;51:559–69.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Winter A, Buring J, Kurth T. Migraine and the risk of becoming overweight and obese: a prospective cohort study. Presented at the American Academy of Neurology, San Diego, March 2013. Available at: http://www.neurology.org/cgi/content/meeting_abstract/78/1_MeetingAbstracts/P04.259?sid=b4e2e84d-5c7e-4f00-984a-fb99ee445108. Accessed Apr 2013.

  28. Bigal ME, Rapoport AM. Obesity and chronic daily headache. Curr Pain Headache Rep. 2012;16:101–9.

    Article  PubMed  Google Scholar 

  29. Scher AI, Stewart WF, Lipton RB. Factors associated with the onset and remission of chronic daily headache in a population-based study. Pain. 2003;106:81–9.

    Article  CAS  PubMed  Google Scholar 

  30. Novack V, Fuch L, Lantsberg L, Kama S, Lahoud U, Horev A, et al. Changes in headache frequency in premenopausal obese women with migraine after bariatric surgery: A case series. Cephalalgia. 2011;31:1336–42.

    Article  CAS  PubMed  Google Scholar 

  31. Verrotti A, Agostinelli S, D’Egidio C, Di Fonzo A, Carotenuto M, Parisi P, et al. Impact of a weight loss program on migraine in obese adolescents. Eur J Neurol. 2013;20:394–7.

    Article  CAS  PubMed  Google Scholar 

  32. Davis JA, Robinson RL, Le TK, Xie J. Incidence and impact of pain conditions and comorbid illnesses. J Pain Res. 2011;4:331–45.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Senna ER, De Barros AL, Silva EO, Costa IF, Pereira LV, Ciconelli RM, et al. Prevalence of rheumatic diseases in Brazil: A study using the COPCORD approach. J Rheumatol. 2004;31:594–7.

    PubMed  Google Scholar 

  34. Lawrence RC, Fleson DT, Helmick CG, Arnold LM, Choi H, Deyo RA, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheumat. 2008;58:26–35.

    Article  PubMed  PubMed Central  Google Scholar 

  35. McNally JD, Matheson DA, Bakowsky VS. The epidemiology of self reported fibromyalgia in Canada. Chronic Dis Can. 2006;27:9–16.

    PubMed  Google Scholar 

  36. Branco JC, Bannwarth B, Failde I, Abello Carbonell J, Blotman F, Spaeth M, et al. Prevalence of fibromyalgia: a survey of five European countries. Semin Arthritis Rheumat. 2010;39:448–53.

    Article  Google Scholar 

  37. de Tommaso M. Prevalence, clinical features and potential therapies for fibromyalgia in primary headaches. Expert Rev Neurother. 2012;12:287–95.

    Article  PubMed  Google Scholar 

  38. Küçükşen S, Genç E, Yilmaz H, Sallı A, Gezer İA, Karahan AY, et al. The prevalence of fibromyalgia and its relation with headache characteristics in episodic migraine. Clin Rheumatol. 2013;32(7):983–90.

    Article  PubMed  Google Scholar 

  39. Marcus DA, Bhowmick A. Fibromyalgia comorbidity in a community sample of adults with migraine. Clin Rheumatol. 2013;32(10):1553–6.

    Article  PubMed  Google Scholar 

  40. Choy E, Perrot S, Leon T, Kaplan J, Petersel D, Ginovker A, et al. A patient survey of the impact of fibromyalgia and the journey to diagnosis. BMC Health Serv Res. 2010;10:102.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Okifuji A, Turk DC, Marcus DA. Comparison of generalized and localized hyperalgesia in patients with recurrent headache and fibromyalgia. Psychosom Med. 1999;61:771–80.

    Article  CAS  PubMed  Google Scholar 

  42. Desmeules JA, Cedraschi C, Rapiti E, Baumgartner E, Finckh A, Cohen P, et al. Neurophysiologic evidence for a central sensitization in patients with fibromyalgia. Arthritis Rheum. 2003;48:1420–9.

    Article  CAS  PubMed  Google Scholar 

  43. Aguggia M, Saracco MG, Cavallini M, Bussone G, Cortelli P. Sensitization and pain. Neurol Sci. 2013;34 suppl 1:37–40.

    Article  Google Scholar 

  44. Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Häuser W, Katz RS, et al. Fibromyalgia criteria and severity scales for clinical and epidemiological studies: a modification of the ACR preliminary diagnostic criteria for fibromyalgia. J Rheumatol. 2011;38:1113–22.

    Article  PubMed  Google Scholar 

  45. Marcus DA, Bernstein C, Albrecht KL. Brief, self-report fibromyalgia screener evaluated in a sample of chronic pain patients. Pain Med. 2013;14:730–5.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Tietjen GE, Peterlin L. Childhood abuse and migraine: epidemiology, sex differences, and potential mechanisms. Headache. 2011;51:869–79.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, et al. Childhood maltreatment and migraine (part I). Prevalence and adult revictimization: a multicenter headache clinic survey. Headache. 2010;50:20–31.

    Article  PubMed  Google Scholar 

  48. Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, et al. Childhood maltreatment and migraine (part II). Emotional abuse as a risk factor for headache chronification. Headache. 2010;50:32–41.

    Article  PubMed  Google Scholar 

  49. Peterlin BL, Ward T, Lidicker J, Levin M. A retrospective, comparative study on the frequency of abuse in migraine and chronic daily headache. Headache. 2007;47:397–401.

    PubMed  Google Scholar 

  50. Cripe SM, Sanchez SE, Gelaye B, Sanchez E, Williams MA. Association between intimate partner violence, migraine and probable migraine. Headache. 2011;51:208–19.

    Article  PubMed  Google Scholar 

  51. Messman-Moore TL, Long PJ. The role of childhood sexual abuse sequelae in the sexual revictimization of women: an empirical review and theoretical reformulation. Clin Psychol Rev. 2003;23:537–71.

    Article  PubMed  Google Scholar 

  52. Norman RE, Byambaa M, De R, Butchart A, Scott J, Vos T. The long-term health consequences of child physical abuse, emotional abuse, and neglect: a systematic review and meta-analysis. PLoS Med. 2012;9:e1001349.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Director TD, Linden JA. Domestic violence: an approach to identification and intervention. Emerg Med Clin North Am. 2004;22:1117–32.

    Article  PubMed  Google Scholar 

  54. Gauthier C. In a medical setting, why and how can the doctor identify the patient as a victim of abuse. Rev Med Liege. 2011;66:424–9.

    CAS  PubMed  Google Scholar 

  55. Lipton RB, Bigal ME, Kolodner K, Stewart WF, Liberman JN, Steiner TJ. The family impact of migraine: population-based studies in the USA and UK. Cephalalgia. 2003;23:429–40.

    Article  CAS  PubMed  Google Scholar 

  56. Dueland AN, Leira R, Burke TA, Hillyer EV, Bolge S. The impact of migraine on work, family, and leisure among young women – a multinational study. Curr Med Res Opin. 2004;20:1595–604.

    Article  PubMed  Google Scholar 

  57. MacGregor EA, Brandes J, Eikermann A, Giammarco R. Impact of migraine on patients and their families: the Migraine and Zolmitriptan Evaluation (MAZE) survey – Phase III. Curr Med Res Opin. 2004;20:1143–50.

    Article  CAS  PubMed  Google Scholar 

  58. Marcus DA, Bhowmick A. Relationship impact in a community sample of adults with migraine [submitted].

    Google Scholar 

  59. Marcus DA, Bhowmick A. Frequency modulates negative impact of migraines on relationships: results on an online survey. Headache. 2013;53(3):551–2.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. University of Pittsburgh, Pittsburgh, PA, USA

    Dawn A. Marcus MD

  2. Fellow American Headache Society, Temple, TX, USA

    Duren Michael Ready MD

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  1. Dawn A. Marcus MD
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  2. Duren Michael Ready MD
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Marcus, D.A., Ready, D.M. (2017). Migraine Is More Than “Just a Headache”. In: Discussing Migraine With Your Patients. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6484-0_4

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  • DOI: https://doi.org/10.1007/978-1-4939-6484-0_4

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