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Pharmacological Inhibitors of Exocytosis and Endocytosis: Novel Bullets for Old Targets

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Exocytosis and Endocytosis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1174))

Abstract

Pharmacological inhibitors of vesicle trafficking possess great promise as valuable analytical tools for the study of a variety of biological processes and as potential therapeutic agents to fight microbial infections and cancer. However, many commonly used trafficking inhibitors are characterized by poor selectivity that diminishes their use in solving basic problems of cell biology or drug development. Recent high-throughput chemical screens intensified the search for novel modulators of vesicle trafficking, and successfully identified a number of small molecules that inhibit exocytosis and endocytosis in different types of mammalian cells. This chapter provides a systematic overview of recently discovered inhibitors of vesicle trafficking. It describes cellular effects and mechanisms of action of novel inhibitors of exocytosis and endocytosis. Furthermore, it pays special attention to the selectivity and possible off-target effects of these inhibitors.

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Acknowledgments

The author thanks Alex Feygin for excellent editorial assistance. This work was supported by National Institute of Health grants RO1 DK083968 and R01 DK084953.

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  1. Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, Virginia Commonwealth University, Goodwin Laboratory, 401 College Street, 980035, Richmond, VA, 23298, USA

    Andrei I. Ivanov

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Correspondence to Andrei I. Ivanov .

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  1. Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, Virginia Commonwealth University, Richmond, Virginia, USA

    Andrei I. Ivanov

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Ivanov, A.I. (2014). Pharmacological Inhibitors of Exocytosis and Endocytosis: Novel Bullets for Old Targets. In: Ivanov, A. (eds) Exocytosis and Endocytosis. Methods in Molecular Biology, vol 1174. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0944-5_1

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  • DOI: https://doi.org/10.1007/978-1-4939-0944-5_1

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