Abstract
The purpose of this paper is to summarise the state of Coronavirus epitope research, with an emphasis laid on the most recent achievements, i.e. the correlation between antigenicity and polypeptide primary structure. The antigenic properties of coronaviruses reside mainly in their envelope glycoproteins: the S (spike) protein, a high molecular weight polypeptide which constitutes the petal-shaped peplomers and the M (membrane) protein, a smaller integral membrane polypeptide. Some coronaviruses possess an additional surface glycoprotein, the haemagglutinin-esterase (HE) protein.
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Keywords
- Infectious Bronchitis Virus
- Escape Mutant
- Protein Recombinant Virus
- High Molecular Weight Polypeptide
- Major Antigenic Site
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Selected Literature
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Lutyes, W., Geerts, D., Posthumus, W., Meloen, R. and Spaan, W. (1989) Amino acid sequence of a conserved neutralising epitope of murine coronaviruses. J. Virol., 63: 1408–1412.
Makino, S., Fleming, J.O., Keck, J.G., Stohlman, S.A. and Lai, M.M.C. (1987) RNA recombination of coronaviruses: localisation of neutralising epitopes and neuropathogenic determinants on the carboxy terminus of peplomers. Proc. Natl. Acad. Sci. USA. 84: 6567–6571.
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Tooze, S.A., and Stanley, K.K. (1986) Identification of two epitopes in the carboxyterminal 15 amino acids of the El glycoprotein of mouse hepatitis virus A%9 by using hybrid proteins. J. Virol. 60: 928–934.
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© 1990 Plenum Press, New York
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Laude, H. (1990). Background Paper Mapping Epitopes on Coronavirus Glycoproteins. In: Cavanagh, D., Brown, T.D.K. (eds) Coronaviruses and their Diseases. Advances in Experimental Medicine and Biology, vol 276. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5823-7_20
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DOI: https://doi.org/10.1007/978-1-4684-5823-7_20
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5825-1
Online ISBN: 978-1-4684-5823-7
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