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Effect of Diet Supplemented with Quinoa Seeds on Oxidative Status in Plasma and Selected Tissues of High Fructose-Fed Rats

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Abstract

Oxidative stress plays an important role as a mediator of damage produced by fructose metabolism. This work was designed to investigate the effect of diet supplemented with quinoa seeds on oxidative stress in plasma, heart, kidney, liver, spleen, lung, testis and pancreas of fructose administered rats. Fructose administration (310 g/kg fodder for 5 weeks) caused oxidative stress that was manifested by the increase in plasma malondialdehyde (MDA) (p<0.05), and by the non-significant changes in the enzymatic antioxidant potential in plasma and most of tissues. Co-administration of quinoa seeds (310 g/kg fodder) maintained normal activities of some enzymes. It also influenced the oxidative stress as was evidenced by decreasing MDA in plasma, and decreasing the activities of antioxidant enzymes (erythrocyte superoxide dismutase - eSOD, catalase -CAT, plasma glutathione peroxidase - pGPX). These findings demonstrate that quinoa seeds can act as a moderate protective agent against potential of fructose-induced changes in rats by reducing lipid peroxidation and by enhancing the antioxidant capacity of blood (plasma) and heart, kidney, testis, lung and pancreas.

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Abbreviations

CAT:

catalase

eSOD:

erythrocyte superoxide dismutase

GPX:

glutathione peroxidase

FRAP:

ferric reducing ability of plasma

MDA:

malondialdehyde

pGPX:

plasma glutathione peroxidase

SOD:

superoxide dismutase

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Acknowledgement

This work was supported in part by the grant PBZ-KBN 094/P06/2003/08 from Polish Ministry of Science and Higher Education.

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Authors and Affiliations

  1. Department of Food Chemistry and Nutrition, Medical College, The Jagiellonian University, Medyczna 9, Kraków, 30–688, Poland

    Pawel Pasko, Henryk Barton, Pawel Zagrodzki, Aleksandra Izewska & Miroslaw Krosniak

  2. Department of Nuclear Physical Chemistry, Henryk Niewodniczański Institute of Nuclear Physic, Kraków, Poland

    Pawel Zagrodzki

  3. Department of Toxicology, Medical College, The Jagiellonian University, Kraków, Poland

    Malgorzata Gawlik & Maciej Gawlik

  4. Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University—Hadassah Medical School, Jerusalem, Israel

    Shela Gorinstein

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  1. Pawel Pasko
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  2. Henryk Barton
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  3. Pawel Zagrodzki
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  4. Aleksandra Izewska
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Correspondence to Pawel Pasko.

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Pasko, P., Barton, H., Zagrodzki, P. et al. Effect of Diet Supplemented with Quinoa Seeds on Oxidative Status in Plasma and Selected Tissues of High Fructose-Fed Rats. Plant Foods Hum Nutr 65, 146–151 (2010). https://doi.org/10.1007/s11130-010-0164-6

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  • DOI: https://doi.org/10.1007/s11130-010-0164-6

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