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Chemical composition and antimicrobial activity of the volatile oils of Geranium sanguineum L. and G. robertianum L. (Geraniaceae)

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Abstract

Volatile compounds of Geranium sanguineum and G. robertianum were isolated by hydrodistillation, analyzed in detail by GC and GC/MS and screened for their in vitro antibacterial and antifungal activity in a microdilution assay. In total, 304 constituents were identified, representing more than 90% of the isolated oils. The volatiles of G. sanguineum have been studied for the first time in this study. The antimicrobial assay showed a strong activity of the G. robertianum oil against Escherichia coli and Aspergillus fumigatus. Micrococcus flavus and A. fumigatus were the most susceptible strains to G. sanguineum oil.

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Acknowledgment

The authors thank the Ministry of Science and Technological Development of Serbia for the financial support of this study (Project No. 172061).

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science and Mathematics, University of Niš, Višegradska 33, 18000, Niš, Serbia

    Niko Radulović & Milan Dekić

  2. Department of Bio-Chemical and Medical Sciences, University of Novi Pazar, Vuka Karadžića bb, 36300, Novi Pazar, Serbia

    Milan Dekić

  3. Department of Biology and Ecology, Faculty of Science and Mathematics, University of Niš, Višegradska 33, 18000, Niš, Serbia

    Zorica Stojanović-Radić

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  1. Niko Radulović
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  2. Milan Dekić
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  3. Zorica Stojanović-Radić
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Correspondence to Niko Radulović.

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Radulović, N., Dekić, M. & Stojanović-Radić, Z. Chemical composition and antimicrobial activity of the volatile oils of Geranium sanguineum L. and G. robertianum L. (Geraniaceae). Med Chem Res 21, 601–615 (2012). https://doi.org/10.1007/s00044-011-9565-9

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  • DOI: https://doi.org/10.1007/s00044-011-9565-9

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